World J Mens Health.  2023 Apr;41(2):373-381. 10.5534/wjmh.210230.

Association between Aortic Calcification Burden and the Severity of Erectile Dysfunction in Men Undergoing Dialysis: A Cross-Sectional Study

• Fujita N
• Hatakeyama S
• Momota M
• Tobisawa Y
• Yoneyama T
• Okamoto T
• Yamamoto H
• Yoneyama T
• Hashimoto Y
• Yoshikawa K
• Ohyama C

• KMID: 2540969
• DOI: http://doi.org/10.5534/wjmh.210230

Abstract

Purpose
Accelerated atherosclerosis is a major complication in patients with end-stage renal disease and it plays an important role in the pathogenesis of erectile dysfunction (ED). However, the association between aortic calcification burden and the severity of ED remains unclear. The aim of the present study was to investigate this association in men undergoing dialysis.
Materials and Methods
This cross-sectional study included 71 men undergoing peritoneal dialysis and/or hemodialysis between July 2016 and May 2018 at Mutsu General Hospital. ED was assessed with the Sexual Health Inventory for Men (SHIM). Patients were divided into the mild/moderate (SHIM score ≥8) and severe ED groups (SHIM score ≤7). Aortic calcification index (ACI) was examined as a clinical indicator of abdominal aortic calcification. Multivariable logistic regression analysis was performed to identify the significant factors associated with severe ED.
Results
The median age of the study participants was 64 years; all had ED, with 64.8% having severe ED. In the multivariable analyses, a slight association was observed between ankle-brachial index and severe ED (odds ratio [OR], 0.058; p=0.072), whereas ACI was significantly associated with severe ED (OR, 1.022; p=0.022).
Conclusions
Aortic calcification burden was independently associated with severe ED.

Keyword

Atherosclerosis; Dialysis; End-stage renal disease; Erectile dysfunction; Vascular calcification