Korean J Vet Res.  2022 Dec;62(4):e31. 10.14405/kjvr.20220020.

Primary copper-associated chronic hepatitis without copper metabolism domain containing 1 mutation in a Dalmatian: a case report

• Yun S
• Lee D
• Oh J
• Chae Y
• Yun T
• Koo Y
• Yang MP
• Kang BT
• Kim H

• KMID: 2540210
• DOI: http://doi.org/10.14405/kjvr.20220020

Abstract

A 12-year-old intact male Dalmatian dog presented hyporexia and vomiting for 1 week. Blood analysis revealed increased liver enzyme activity. Histopathological examination of the liver confirmed chronic hepatitis with fibrosis and necrosis. Copper staining revealed marked copper accumulation (2,770 ppm; normal range, 200 to 400 ppm), prominent in the centrilobular region, and compatible with copper-associated chronic hepatitis. However, copper metabolism domain containing 1 (COMMD1) mutation predisposing to copper accumulation in the liver tissue was not identified. The dog received medications but died 1 month after first visit. This is the first case of primary copper-associated hepatitis without COMMD1 mutation in a Dalmatian dog in South Korea.

Keyword

dogs; liver; penicillamine; rhodamines; canine; proton pump inhibitors; vomiting