Acute Crit Care.  2022 Nov;37(4):644-653. 10.4266/acc.2022.00395.

Characteristics and timing of mortality in children dying in pediatric intensive care: a 5-year experience

Affiliations
  • 1Division of Pediatric Intensive Care, Department of Pediatrics, Ankara University School of Medicine, Ankara, Türkiye
  • 2Department of Pediatrics, Ankara University School of Medicine, Ankara, Türkiye

Abstract

Background
Pediatric intensive care units (PICUs), where children with critical illnesses are treated, require considerable manpower and technological infrastructure in order to keep children alive and free from sequelae. Methods: In this retrospective comparative cohort study, hospital records of patients aged 1 month to 18 years who died in the study PICU between January 2015 and December 2019 were reviewed. Results: A total of 2,781 critically ill children were admitted to the PICU. The mean±standard deviation age of 254 nonsurvivors was 64.34±69.48 months. The mean PICU length of stay was 17 days (range, 1–205 days), with 40 children dying early (<1 day of PICU admission). The majority of nonsurvivors (83.9%) had comorbid illnesses. Children with early mortality were more likely to have neurological findings (62.5%), hypotension (82.5%), oliguria (47.5%), acidosis (92.5%), coagulopathy (30.0%), and cardiac arrest (45.0%) and less likely to have terminal illnesses (52.5%) and chronic illnesses (75.6%). Children who died early had a higher mean age (81.8 months) and Pediatric Risk of Mortality (PRISM) III score (37). In children who died early, the first three signs during ICU admission were hypoglycemia in 68.5%, neurological symptoms in 43.5%, and acidosis in 78.3%. Sixty-seven patients needed continuous renal replacement therapy, 51 required extracorporeal membrane oxygenation support, and 10 underwent extracorporeal cardiopulmonary resuscitation. Conclusions: We found that rates of neurological findings, hypotension, oliguria, acidosis, coagulation disorder, and cardiac arrest and PRISM III scores were higher in children who died early compared to those who died later.

Keyword

cause of death; children; extracorporeal membrane oxygenation; mortality; pediatric intensive care units; sepsis

Figure

  • Figure 1. Flowchart of patients who died in pediatric intensive care.

  • Figure 2. (A) Numbers of admissions and nonsurvivors annually from 2015 to 2019. (B) Annual mortality rates.

  • Figure 3. (A) Procedures based on timing of death, including extracorporeal membrane oxygenation (ECMO; veno-venous [VV] or veno-arterial [VA]), plasma exchange (PEX), and continuous renal replacement therapy (CRRT) (≤1 or ≥2 day). (B) Location prior to pediatric intensive care unit (PICU) admission based on timing of death, including from the institution’s own emergency department or operating room and transfer from other hospitals. Patients transported from the neonatal ICU and pediatric wards of the hospital. (C) Diagnosis based on timing of death in the PICU.


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