Acute Crit Care.  2024 Nov;39(4):600-610. 10.4266/acc.2024.01011.

Post–intensive-care morbidity among pediatric patients in Thailand: prevalence, risk factors, and the importance of the post–intensive-care clinic

Affiliations
  • 1Division of Pediatric Critical Care, Department of Pediatrics, Thammasat University Hospital, Faculty of Medicine, Thammasat University, Pathumthani, Thailand

Abstract

Background
Long-term survival data for critically ill children discharged to post-intensive care clinics are scarce, especially in Asia. The main objective of this study was to assess the prevalence of post–intensive-care morbidity among pediatric intensive care unit (PICU) survivors at 1 month and 1 year after hospital discharge and to identify the associated risk factors.
Methods
We conducted a retrospective chart review of all children aged 1 month to 15 years who were admitted to the PICU for >48 hours from July 2019 to July 2022 and visited a post–intensive-care clinic 1 month and 1 year after hospital discharge. Post-intensive care morbidity was defined using the Pediatric Cerebral Performance Category (PCPC). Descriptive statistics, univariate, and multivariate analyses were conducted.
Results
A total of 111 children visited the clinic at 1 month, and 100 of these children visited the clinic at 1 year. Only 39 of 111 children (35.2%) had normal PCPC assessments at 1 month, while 54 of 100 (54.0%) were normal at 1 year. Baseline developmental delays were significantly associated with any degree of disability and at least moderate disability at both time points. Mechanical ventilation for >7 days was associated with at least moderate disability at both time points, while PICU stay >7 days was significantly associated with moderate disability at 1 month and any degree of disability at 1 year.
Conclusions
A substantial percentage of PICU survivors had persistent disabilities even 1 year after critical illness. A structured multidisciplinary post–intensive-care follow-up plan is warranted to provide optimal care for such children.

Keyword

children; intensive care; morbidity

Figure

  • Figure 1. Population flowchart. PICU: pediatric intensive care unit.


Reference

1. Manning JC, Pinto NP, Rennick JE, Colville G, Curley MA. Conceptualizing post intensive care syndrome in children: the PICS-p framework. Pediatr Crit Care Med. 2018; 19:298–300.
Article
2. Inoue S, Hatakeyama J, Kondo Y, Hifumi T, Sakuramoto H, Kawasaki T, et al. Post-intensive care syndrome: its pathophysiology, prevention, and future directions. Acute Med Surg. 2019; 6:233–46.
Article
3. Herrup EA, Wieczorek B, Kudchadkar SR. Characteristics of postintensive care syndrome in survivors of pediatric critical illness: a systematic review. World J Crit Care Med. 2017; 6:124–34.
Article
4. Ong C, Lee JH, Leow MK, Puthucheary ZA. Functional outcomes and physical impairments in pediatric critical care survivors: a scoping review. Pediatr Crit Care Med. 2016; 17:e247–59.
Article
5. Als LC, Picouto MD, Hau SM, Nadel S, Cooper M, Pierce CM, et al. Mental and physical well-being following admission to pediatric intensive care. Pediatr Crit Care Med. 2015; 16:e141–9.
Article
6. Jones S, Rantell K, Stevens K, Colwell B, Ratcliffe JR, Holland P, et al. Outcome at 6 months after admission for pediatric intensive care: a report of a national study of pediatric intensive care units in the United kingdom. Pediatrics. 2006; 118:2101–8.
Article
7. Gemke RJ, Bonsel GJ, van Vught AJ. Long-term survival and state of health after paediatric intensive care. Arch Dis Child. 1995; 73:196–201.
Article
8. Tippayawong P, Chaiyakulsil C. Incidence and associated factors of pediatric post-intensive care syndrome using the VSCAREMD model. Acute Crit Care. 2022; 37:627–35.
Article
9. Als LC, Nadel S, Cooper M, Pierce CM, Sahakian BJ, Garralda ME. Neuropsychologic function three to six months following admission to the PICU with meningoencephalitis, sepsis, and other disorders: a prospective study of school-aged children. Crit Care Med. 2013; 41:1094–103.
10. Colville G, Pierce C. Patterns of post-traumatic stress symptoms in families after paediatric intensive care. Intensive Care Med. 2012; 38:1523–31.
Article
11. Dow BL, Kenardy JA, Le Brocque RM, Long DA. The diagnosis of posttraumatic stress disorder in school-aged children and adolescents following pediatric intensive care unit admission. J Child Adolesc Psychopharmacol. 2013; 23:614–9.
Article
12. Walz A, Canter MO, Betters K. The ICU liberation bundle and strategies for implementation in pediatrics. Curr Pediatr Rep. 2020; 8:69–78.
Article
13. Snell K, Rekha RM, Herring M, Hussein R, Korzick K, Layon A. Post-intensive care unit clinic (PICUC) role in decreasing 60-day readmissions: a prospective study. Crit Care Med. 2018; 46:590.
Article
14. de Sonnaville ES, Kӧnigs M, Aarnoudse-Moens CS, van Woensel JB, Oosterlaan J, Knoester H. Long-term follow-up of daily life functioning after pediatric intensive care unit admission. J Pediatr. 2023; 260:113477.
Article
15. Fiser DH. Assessing the outcome of pediatric intensive care. J Pediatr. 1992; 121:68–74.
Article
16. Volaki EM, Sdougka MM, Mantzafleri PE, Tsonidis CH, Kontopoulos E, Tsikoulas I. Functional outcome following pediatric intensive care: Pediatric Cerebral Performance Category (PCPC) and Pediatric Overall Performance Category (POPC) during a prospective two years follow-up period. Greek eJ Perioper Med. 2015; 13:2–15.
17. Pollack MM, Patel KM, Ruttimann UE. PRISM III: an updated Pediatric Risk of Mortality score. Crit Care Med. 1996; 24:743–52.
18. Belletti A, Lerose CC, Zangrillo A, Landoni G. Vasoactive-inotropic score: evolution, clinical utility, and pitfalls. J Cardiothorac Vasc Anesth. 2021; 35:3067–77.
Article
19. Odetola F, Pappachan J. What challenges still exist in the critical care of children? BMC Pediatr. 2022; 22:592.
Article
20. Heneghan JA, Sobotka SA, Hallman M, Pinto N, Killien EY, Palumbo K, et al. Outcome measures following critical illness in children with disabilities: a scoping review. Front Pediatr. 2021; 9:689485.
Article
21. Fink EL, Maddux AB, Pinto N, Sorenson S, Notterman D, Dean JM, et al. A core outcome set for pediatric critical care. Crit Care Med. 2020; 48:1819–28.
22. Fiser DH, Tilford JM, Roberson PK. Relationship of illness severity and length of stay to functional outcomes in the pediatric intensive care unit: a multi-institutional study. Crit Care Med. 2000; 28:1173–9.
Article
Full Text Links
  • ACC
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2025 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr