Clin Mol Hepatol.
2023 Feb;29(Suppl):S17-S31. 10.3350/cmh.2022.0367.
MAFLD: How is it different from NAFLD?
- Gofton C
1,2,3,4 - Upendran Y1
- Zheng MH5,6,7,8
- George J1
- Affiliations
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- 1Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia
- 2Department of Gastroenterology and Hepatology, Royal North Shore Hospital, St Leonards, NSW, Australia
- 3Department of Gastroenterology and Hepatology, Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia
- 4Department of Gastroenterology and Hepatology, University of New South Wales, Sydney, NSW, Australia
- 5MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
- 6Wenzhou Key Laboratory of Hepatology, Wenzhou, China
- 7Institute of Hepatology, Wenzhou Medical University, Wenzhou, China
- 8Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China
- KMID: 2539787
- DOI: http://doi.org/10.3350/cmh.2022.0367
Abstract
- “Metabolic dysfunction-associated fatty liver disease (MAFLD)” is the term suggested in 2020 to refer to fatty liver disease related to systemic metabolic dysregulation. The name change from nonalcoholic fatty liver disease (NAFLD) to MAFLD comes with a simple set of criteria to enable easy diagnosis at the bedside for the general medical community, including primary care physicians. Since the introduction of the term, there have been key areas in which the superiority of MAFLD over the traditional NAFLD terminology has been demonstrated, including for the risk of liver and extrahepatic mortality, disease associations, and for identifying high-risk individuals. Additionally, MAFLD has been adopted by a number of leading pan-national and national societies due to its concise diagnostic criterion, removal of the requirement to exclude concomitant liver diseases, and reduction in the stigma associated with this condition. The current article explores the differences between MAFLD and NAFLD diagnosis, areas of benefit, some potential limitations, and how the MAFLD terminology has opened up new fields of research.
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