J Vet Sci.  2023 Jan;24(1):e6. 10.4142/jvs.22101.

Delayed periocular dermatitis as a rare side-effect of topical antiglaucoma eyedrop instillation in two Shih-Tzu dogs with atopic dermatitis

Affiliations
  • 1Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea

Abstract

Two Shih-Tzu dogs with atopic dermatitis presented with delayed periocular dermatitis (PD) following the instillation of dorzolamide and dorzolamide/timolol combination eyedrops; the development of dermatologic signs took 94 and 104 d in cases 1 and 2, respectively. Hypersensitivity to anti-glaucoma eyedrops was highly suspected, and treatment was discontinued. Delayed PD was significantly relieved in cases 1 and 2, at days 155 and 64 after discontinuation, respectively. In this study, the clinical characteristics and progression of delayed PD were described to inform clinicians who may encounter this rare side effect.

Keyword

Atopic dermatitis; carbonic anhydrase inhibitor; dorzolamide; delayed periocular dermatitis; hypersensitivity
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