Investig Magn Reson Imaging.
2022 Dec;26(4):200-207. 10.13104/imri.2022.26.4.200.
Diffusion MRI With High to Ultrahigh b-Values: How It Will Benefit the Discovery of Brain Microstructure and Pathological Changes
- Wongkornchaovalit P
1,2 - Feng M1,2
- He H1,2
- Zhong J1,3
- Affiliations
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- 1Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China
- 2Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, Zhejiang, China
- 3Department of Imaging Sciences, University of Rochester, Rochester, NY, USA
- KMID: 2538306
- DOI: http://doi.org/10.13104/imri.2022.26.4.200
Abstract
- Diffusion MRI (dMRI) has been widely utilized to probe the random motion of water molecules in tissues. In a dMRI acquisition protocol, diffusion weighting or b-value is one of the most important parameters to consider. In recent years, high and ultrahigh b-values have become popular partly due to advances in hardware. In this mini-review, we will discuss impacts of high/ultrahigh b-values in three different areas: brain microstructure, tractography, and clinical applications. We will emphasize advantages of high b-value in probing diffusion within highly restricted regions or fine structures with enhanced diffusion contrast. A short summary is included at the end of each section to illustrate both advantages and disadvantages of using a high/ultrahigh b-value for each purpose.
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