Lab Anim Res.
2022 Dec;38(4):271-286. 10.1186/s42826-022-00150-3.
Anesthesia and analgesia for common research models of adult mice
- Ahmadi‑Noorbakhsh S
1,2 - Abbasi M3
- Ghasemi M4
- Bayat G5
- Davoodian N6
- Sharif‑Paghaleh E1,7,8
- Poormoosavi S9
- Rafizadeh M10
- Maleki M11
- Shirzad‑Aski H12
- Jahromi H13
- Dadkhah M14
- Khalvati B15
- Safari T16,17
- Behmanesh M18
- Khoshnam S19
- Houshmand G20
- Talaei S21
- Affiliations
-
- 1Preclinical Core Facility (TPCF), Tehran University of Medical Sciences, Tehran, Iran
- 2The National Ethics Committee for Biomedical Research, Floor 13th, Complex A, Ministry of Health and Medical Education, Eyvanak Blvd., Shahrake Gharb, Tehran, Iran.
- 3Neuroscience Research Center, Institute of Neurophar‑ macology, Kerman University of Medical Sciences, Kerman, Iran
- 4Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfa‑ han, Iran.
- 5Department of Physiology‑Pharmacology‑Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
- 6Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sci‑ ences, Bandar Abbas, Iran.
- 7Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
- 8Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sci‑ ences, Faculty of Life Sciences and Medicine, King’s College London, London, England.
- 9Department of Histology, School of Medicine, Research and Clini‑ cal Center for Infertility, Dezful University of Medical Sciences, Dezful, Iran.
- 10Department of Pharmacology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- 11Department of Physiology, Faculty of Medi‑ cine, Ilam University of Medical Sciences, Ilam, Iran.
- 12Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
- 13Research Center for Non‑Communicable Disease, Jahrom University of Medi‑ cal Sciences, Jahrom, Iran.
- 14Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
- 15Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
- 16School of Medicine, Department of Physiology, PhD, Zahedan University of Medical Sciences, Zahedan, Iran.
- 17Pharmacology Research Center, Zahedan University of Medi‑ cal Sciences, Zahedan, Iran.
- 18Department of Histology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran.
- 19Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
- 20Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Department of Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
- 21Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
- KMID: 2537628
- DOI: http://doi.org/10.1186/s42826-022-00150-3
Abstract
- Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals and published articles. In many cases, it seems “anesthesia” and “analgesia” are used interchangeably, while they are referring to two different concepts. Not only this is an unethical practice, but also it may be one of the reasons for the proven sub‑ optimal quality of many animal researches. This is a widespread problem among investigations on various species of animals. However, it could be imagined that it may be more prevalent for the most common species of laboratory animals, such as the laboratory mice. In this review, proper anesthetic/analgesic methods for routine procedures on laboratory mice are discussed. We considered the available literature and critically reviewed their anesthetic/analge‑ sic methods. Detailed dosing and pharmacological information for the relevant drugs are provided and some of the drugs’ side effects are discussed. This paper provides the necessary data for an informed choice of anesthetic/analge‑ sic methods in some routine procedures on laboratory mice.
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