Tuberc Respir Dis.  2023 Jan;86(1):14-22. 10.4046/trd.2022.0081.

Update on Adjuvant Treatment in Resectable Non-Small Cell Lung Cancer and Potential Biomarkers Predicting Postoperative Relapse

• Lim JU

• KMID: 2537199
• DOI: http://doi.org/10.4046/trd.2022.0081

Abstract

A significant proportion of patients with non-small cell lung cancer (NSCLC) is diagnosed in the early and resectable stage. Despite the use of platinum-based adjuvant chemotherapy, there was only a marginal increase in overall survival and a 15% decrease in relapse. With the advents of immunotherapy and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), the landscape of adjuvant treatment in completely resectable NSCLC is changing. Postoperative radiotherapy can be beneficial to patients who underwent surgical resection in certain clinical settings. In addition, new biomarkers that predict efficacy of EGFR TKI and immunotherapy as adjuvant treatment are also necessary. In this review, recent updates in adjuvant treatment in resectable NSCLC were briefly explained.

Keyword

Carcinoma, Non-Small-Cell Lung; Protein Kinase Inhibitors; Chemotherapy, Adjuvant; Recurrence; Biomarkers