Korean J Sports Med.  2022 Dec;40(4):252-258. 10.5763/kjsm.2022.40.4.252.

Effects of Prior Short-term Ischemic Preconditioning on Sitting-Induced Lower Limb Vascular Dysfunction in Healthy Men

• Won JH
• Jae SY

• KMID: 2536676
• DOI: http://doi.org/10.5763/kjsm.2022.40.4.252

Abstract

Purpose
The purpose of the study was to examine whether a 7-day ischemic preconditioning (IPC) intervention would attenuate the prolonged sitting-induced lower limb vascular dysfunction in healthy men.
Methods
In a randomized control trial, 12 healthy men (age, 24.9±2.6 years) were assigned to either a 7-day IPC intervention (6×5 minutes of bilateral thigh cuff occlusions at 200 mm Hg) or a sham control group (6×5 minutes of bilateral thigh cuff occlusions at 20 mm Hg). After the 7-day IPC intervention, the participants underwent a 4-hour prolonged sitting. We measured blood pressure, central blood pressure, and superficial femoral artery flow-mediated dilation at baseline (before intervention), pre-sitting (after intervention), post-2-hour sitting, and post-4-hour sitting.
Results
During the 4-hour sitting time, blood pressure and central blood pressure did not significantly change from baseline in any group. However, superficial femoral artery flow-mediated dilation decreased from baseline more so in the sham control group (5.2±1.9 to 1.7±1.2) compared with the IPC group (4.6±2.2 to 3.1±1.5, p=0.015 for interaction).
Conclusion
These findings demonstrate that a 7-day IPC protected against lower limb vascular dysfunction during prolonged sitting in healthy men.

Keyword

Ischemic preconditioning; Sedentary behavior; Vascular system injuries

Figure

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  Fig. 1 Experimental design. (A) Group design. (B) Schematic diagram of this study. IPC: ischemic preconditioning, FMD: flow-mediated dilation.

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  Fig. 2 Comparison of changes in superficial femoral artery flow-mediated dilation (SFA FMD) between before and after 4-hour sitting in ischemic preconditioning group (IPC) and sham control group (Sham). p-value for independent t-test between IPC and Sham.

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