Korean J Dermatol.
2022 Nov;60(9):615-617.
Successful Treatment of Palmoplantar Arsenical Keratosis with a Combination of Alitretinoin and Cryotherapy
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- 1Department of Dermatology, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea
Abstract
- Chronic arsenic exposure causes varied dermatological sequelae, from arsenical keratosis to skin cancers. We report the successful treatment of palmoplantar arsenical keratosis with a combination of systemic alitretinoin and cryotherapy. A 49-year-old Korean man with a history of taking a traditional medicine formulation for 6 months in his early 30s was diagnosed with multiple cutaneous squamous carcinomas with metastasis to lymph node, squamous carcinoma in situ, and palmoplantar arsenical keratosis. Wide local excision followed by adjuvant radiotherapy was done for the malignancies, and palmoplantar arsenical keratosis was treated with systemic alitretinoin (30 mg/d) and cryotherapy. The patient tolerated the treatment well, and arsenical keratosis was nearly cleared after 18 months.
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