Psychiatry Investig.
2022 Nov;19(11):949-957. 10.30773/pi.2022.0078.
The Effect of Temperament on the Association Between Pre-treatment Anxiety and Chemotherapy-Related Symptoms in Patients With Breast Cancer
- Choi JI
1,2 - Jung S3,4
- Oh GH5
- Son KL6
- Lee KM7
- Jung D8
- Kim TY9,10
- Im SA9,10,11
- Lee KH9,10
- Shin MS4
- Hahm BJ2,4
- Yeom CW12
- Affiliations
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- 1Department of Clinical Medical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
- 2Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
- 3Department of Psychiatry, National Rehabilitation Center, Seoul, Republic of Korea
- 4Department of Psychiatry and Behavioral Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
- 5Public Health Medical Service, Seoul National University Hospital, Seoul, Republic of Korea
- 6Department of Psychiatry, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
- 7Mind Lab the Place, Seoul, Republic of Korea
- 8Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea
- 9Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
- 10Cancer Research Institute, Seoul National University, Seoul, Republic of Korea
- 11Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
- 12Department of Psychiatry, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, Republic of Korea
- KMID: 2536201
- DOI: http://doi.org/10.30773/pi.2022.0078
Abstract
Objective
Pre-treatment anxiety (PA) before chemotherapy increases complaints of chemotherapy-related symptoms (CRS). The results on the association have been inconsistent, and the effect of temperament remains unclear. We aimed to determine whether PA is a risk factor for CRS and the effect of differing temperaments on CRS.
Methods
This prospective study comprised 176 breast cancer patients awaiting adjuvant chemotherapy post-surgery. We assessed CRS, PA, and temperament using the MD Anderson Symptom Inventory (MDASI), the Hospital Anxiety and Depression Scale, and the short form of the Temperament and Character Inventory-Revised, respectively. The MDASI was re-administered three weeks after the first chemo-cycle.
Results
PA showed weak positive correlation with several CRS after the first cycle; no CRS was significantly associated with PA when pre-treatment depressive symptoms and baseline CRS were adjusted in multiple regression analysis. Moderation model analysis indicated that the PA effect on several CRS, including pain, insomnia, anorexia, dry mouth, and vomiting, was moderated by harm avoidance (HA) but not by other temperament dimensions. In particular, PA was positively associated with CRS in patients with low HA.
Conclusion
The results in patients with low HA indicate that more attention to PA in patients with confident and optimistic temperaments is necessary.
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