Korean J Transplant.  2022 Nov;36(Supple 1):S195. 10.4285/ATW2022.F-3297.

Impact factors leading to renal impairment after liver transplant surgery: a single center study

• Batsuuri B
• Avirmed S
• Badarch BI
• Lopez-Verdugo 3 , F
• Togtokh A
• Avirmed S
• Orgoi S

• KMID: 2535711
• DOI: http://doi.org/10.4285/ATW2022.F-3297

Abstract

Background
Mongolia is known as one of the countries with a high prevalence of viral hepatitis infection and its related liver cirrhosis and hepatocellular carcinoma. Therefore, liver transplantation (LT) surgery increases from year to year in Mongolia. Liver transplant recipients frequently develop renal impairment, but the predisposing factors and long-term consequences of renal impairment are not well understood. Our goal was to evaluate posttransplant renal dysfunction (PTRD) and to investigate the predicting factors for renal dysfunction after LT.
Methods
This is a hospital-based case control study of 167 consecutive cases undergoing LT between September 2011 and September 2022. Early renal impairment was identified by measuring serum creatinine at pretransplantation, interoperatively, 24 hours, 72 hours, 7 days, 14 days, 28 days post-LT. Patients with and without renal impairment were compared to identify risk factors associated with this complication. The impact graft ischemic time, peri- and postoperative blood product transfusion, perioperative hemodynamics, on time to extubation, intensive care length of stay, incidence of chronic renal failure, mortality and morbidity were examined alone and then as a combined outcome. Collected each recipient data by survey card and fill out the card in accordance with the questionnaire.
Results
Early renal dysfunction was identified by measuring serum creatinine and glomerular filtration rate. In our investigation which was a study group of patients following LT, the following renal dysfunctions were found: 46.7% of recipients in the study had renal dysfunction, while the rest its 4.8% had renal dysfunction preoperatively. The average creatinine level of the recipients who had a renal dysfunction after LT, was 0.825±0.24 mg/dL and the glomerular filtration rate was 111±36.3 mL/min, and statistically significant.
Conclusions
According to a study of the recipient side effects of renal failure after liver transplantation, preoperative kidney function plays a crucial role for postoperative renal dysfunction.