Korean J Transplant.  2022 Nov;36(Supple 1):S105. 10.4285/ATW2022.F-2229.

Outcomes of liver transplant recipients in 5 years postoperative period

• Than CPP
• Mar TT

• KMID: 2535621
• DOI: http://doi.org/10.4285/ATW2022.F-2229

Abstract

Background
Liver transplantation (LT) is a highly successful treatment for patients with end-stage liver disease and acute liver failure. The aim of this study was to review the outcomes such as morbidity and mortality of adult living donor liver transplant recipients within 5 years of postoperative period.
Methods
Medical records of 30 liver transplant recipients during 2016 October to 2019 December period at the Department of Hepatobiliary and Pancreatic Surgery, Yangon Specialty Hospital have been evaluated retrospectively. In this study, primary outcome that was patient survival and secondary outcome like late complications (including surgical complications, postoperative biliary complications and medical complications infection, chronic rejection, recurrence of primary disease and posttransplant metabolic syndrome and major cardiovascular events) were reviewed.
Results
Regarding the primary outcome, 1-year survival was 73 %, 3-year survival was 50% and 5-year survival was 43%. Bili-ary complications were the most frequent postoperative complications of liver transplant patients. Eight out of 30 patients face with biliary complications range from early anastomotic leak to late stricture and obstruction in the extra-hepatic or intra-hepatic biliary system. In this 5 years study, the rate of tumor recurrence after transplant is patients with hepatocellular carcino- ma is 35%. Approximately 60% of tumor recurrence occurred after third year of LT and only three cases were detected during the first 2 years after LT. Regarding the medical complication, severe infectious complication occurred in two post-LT recipients, minor infection occurred in three patients, and only two patients faced with chronic rejection and four patients over 5-year survival had hypertension.
Conclusions
Improvement in immunosuppression, perioperative management, and surgical techniques made a decrease in perioperative mortality and short-term survival has improved. However long-term complications have not been fully elucidated. Analysis of chronic complications individually give a chance to find the possible risk factors and to improve long-term outcomes after LT.