Korean J Transplant.  2022 Nov;36(Supple 1):S215. 10.4285/ATW2022.F-3538.

Prevention therapy in patients with the severу hepatorenal syndrome

• Sultangereyev Y
• Mussin N
• Rysmakhanov M

• KMID: 2535280
• DOI: http://doi.org/10.4285/ATW2022.F-3538

Abstract

Background
Hepatorenal syndrome (HRS) plays an important role in patients with liver cirrhosis before liver transplantation. To determine the dynamics of the severity of the condition and prediction of the estimated risk of mortality (ERM) patients with HRS using cellular mediators.
Methods
The study included a group of nine patients with HRS in ages from 22 to 64 years. Six patients of the main group re-ceived cell mediators. Inside the main group investigated patients were divided into three groups (moderate, severe and very severe) depending on the number of points. Assessment of the dynamics of flow multiple organ failure (MOF) performed before treatment, 3–5 days and 7–10 days of treatment.
Results
According to the results of intragroup analysis revealed statistically significant dynamic changes in the main group for the subgroup of moderate severity. Decrease in the average scores in the subgroup indicates positive patient outcomes. Comparison between subgroups and control group showed no statistical differences in the dynamics of APACHE III. The exception were two subgroups moderate groups where there was a statistically significant difference in the initial state–prior to treatment. This is due to the small sample of patients, where the average score was higher APACHE III in the study group than in the control. At subsequent stages of observation for 3–5 and 7–10 day these differences offset due to the patients. The dynamics of the estimated risk of death in one and two subgroup of the main group shows a statistically significant decrease of this indicator.
Conclusions
The use of cellular mediators can be combine in the complex therapy of patients with HRS before liver transplantation. The expediency of using cellular mediators in patients with HRS remains controversial and requires additional evidence in studies.