Korean J Med.  2016 May;90(5):384-388. 10.3904/kjm.2016.90.5.384.

Hepatorenal Syndrome

• Lee JP

• KMID: 2163230
• DOI: http://doi.org/10.3904/kjm.2016.90.5.384

Abstract

Hepatorenal syndrome is a functional renal failure occurred in end-stage liver disease. It is regarded as one of the most serious complications of liver disease; commonly occur in patients with cirrhosis or acute liver failure. Pathophysiologically, portal hypertension induced vasoconstriction in the renal cortex reduces glomerular filtration rate. There are no intrinsic renal diseases or histological abnormalities. In most patients, the natural course of the renal failure leads to fatal consequences, even though various treatment options have been provided. Liver transplantation and combination therapy of albumin and vasopressin analogs can restore the damage of the blood vessel.

Keyword

Hepatorenal syndrome; Cirrhosis; Renal failure; Transplantation; Terlipressin

MeSH Terms

Blood Vessels
Fibrosis
Glomerular Filtration Rate
Hepatorenal Syndrome*
Humans
Hypertension, Portal
Liver Diseases
Liver Failure, Acute
Liver Transplantation
Renal Insufficiency
Transplantation
Vasoconstriction
Vasopressins
Vasopressins