Korean J Transplant.  2022 Nov;36(Supple 1):S48. 10.4285/ATW2022.F-1642.

The results after induction of rabbit anti-thymocyte globulin in the deceased donor kidney transplantation using the grafts of above kidney donor profile index score >65%

• Moon JI
• Lee SJ
• Choi IS

• KMID: 2535252
• DOI: http://doi.org/10.4285/ATW2022.F-1642

Abstract

Background
There are limited data concerning the benefits and adverse effects associated with different induction regimens in kidney transplant recipients using the high kidney donor profile index (KDPI) grafts. The aim of this study is to evaluate the outcome after rabbit anti-thymocyte globulin (rATG) induction with deceased donor kidney transplantation using the graft above KDPI score of 65%.
Methods
Between June 2011 and July 2022, 85 patients underwent deceased donor kidney transplantation at Department of Surgery at Konyang University Hospital, Daejeon, Korea. Recipients were divided into two groups; the high KDPI+rATG group A: n=34 and the low KDPI+basiliximab group B: n=28. The following characteristics were evaluated retrospectively through the medical records.
Results
The 5-year patient survival in the group A was 87.0% compared to 88.4% in the group B (P=0.986). Graft survival at 5-year was 93.5% and 96.4% in the group A and the group B (P=0.873) respectively. Creatinine level by period of recipients was more increased in group A. But, creatinine level of recipients at 60th months and 72nd months was not significantly different in both groups. Complications during the follow periods and delayed graft function (DGF) was tended to increase in the rATG group groups (79.4% vs. 53.6%, P=0.055 and 23.5% vs. 7.1%, P=0.097).
Conclusions
The results show that patient survival and graft survival after induction of ATG of the deceased donor kidney transplantation using the high KDPI grafts is not different. Creatinine levels of recipients at long term periods were not significantly different in both groups. But complications and DGF was tended to increase in the deceased donor kidney transplantation using the high KDPI grafts after induction of rATG.