J Gastric Cancer.  2022 Mar;22(1):3-23. 10.5230/jgc.2022.22.e10.

A Comprehensive and Comparative Review of Global Gastric Cancer Treatment Guidelines

• Eom SS
• Choi W
• Eom BW
• Park SH
• Kim SJ
• Kim YI
• Yoon HM
• Lee JY
• Kim CG
• Kim HK
• Kook MC
• Choi IJ
• Kim YW
• Park YI
• Ryu KW

• KMID: 2535083
• DOI: http://doi.org/10.5230/jgc.2022.22.e10

Abstract

Countries differ in their treatment expertise and research results regarding gastric cancer; hence, treatment guidelines are diverse based on evidence and medical situations. A comprehensive and comparative review of each country’s guidelines is imperative to understand the similarities and differences among countries. We reviewed and compared five gastric cancer treatment guidelines in terms of endoscopic, surgical, perioperative, and palliative systemic treatment based on evidence levels and recommendation grades, as well as the postoperative follow-up strategies for each guideline. The Korean, Chinese, and European guidelines provided evidence and grading of the recommendations. The United States guidelines suggested categories for evidence and consensus. The Japanese guidelines suggested evidence and recommendations only for systemic treatment. The Korean and Japanese guidelines described endoscopic treatment, surgery, and lymphadenectomy in detail. The Chinese, United States, and European guidelines more intensively considered perioperative chemotherapy. In particular, the indications for chemotherapy and the regimens recommended by each guideline differed slightly. Considering their medical situations, each guideline had some diversity in terms of adopting evidence, which resulted in heterogeneous recommendations. This review will help medical personnel to comprehensively understand the diversity in gastric cancer treatment guidelines for each country in terms of evidence and recommendations.

Keyword

Gastric cancer; Guideline; Review; Treatment