Ewha Med J.  2022 Oct;45(4):e17. 10.12771/emj.2022.e17.

Coronary Spasm during General Anesthesia in a Patient with Previously Undiagnosed Variant Angina

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Ewha Womans University Medical Center Mokdong Hospital, Seoul, Korea
  • 2Department of Anesthesiology and Pain Medicine, College of Medicine, Ewha Womans University, Seoul, Korea

Abstract

Variant angina, which is associated with coronary artery spam, is difficult to recognize on routine preoperative evaluation. Coronary spasm results in myocardial ischemia and even lethal arrhythmia in severe cases. Since patients are unconscious and cannot complain of symptoms during general anesthesia, early detection of such an event is difficult, and it could lead to severe bradycardia or cardiac arrest. We report a case of a patient with previously undiagnosed variant angina who experienced severe hypotension and ventricular fibrillation during general anesthesia.

Keyword

Coronary vasospasm; Anesthesia; general; Hypotension; Angina pectoris; variant; Ventricular fibrillation

Figure

  • Fig. 1. Electrocardiography following coronary vasospasm. (A) ST-segment elevation at the leads V2–V4 was noted when the patient’s blood pressure decreased. Immediately following this observation, ventricular fibrillation was noted. After one cycle of cardiopulmonary resuscitation, a return of spontaneous circulation (ROSC) was achieved. (B) ST-segment elevation normalized shortly after ROSC.

  • Fig. 2. Emergency coronary angiography. (A) and (B) No stenotic lesions were detected in the left and right coronary arteries. (C) Dilation of the right coronary artery was observed after intravenous administration of nitroglycerin.


Reference

References

1. Song JK. Coronary artery vasospasm. Korean Circ J. 2018; 48(9):767–777. DOI: 10.4070/kcj.2018.0251. PMID: 30146803. PMCID: PMC6110699.
Article
2. Kishida H, Tada Y, Fukuma N, Saitoh T, Kusama Y, Sano J. Significant characteristics of variant angina patients with associated syncope. Jpn Heart J. 1996; 37(3):317–326. DOI: 10.1536/ihj.37.317. PMID: 8774624.
Article
3. Prinzmetal M, Kennamer R, Merliss R, Wada T, Bor N. Angina pectoris I. A variant form of angina pectoris: preliminary report. Am J Med. 1959; 27(3):375–388. DOI: 10.1016/0002-9343(59)90003-8.
4. Lanza GA, Careri G, Crea F. Mechanisms of coronary artery spasm. Circulation. 2011; 124(16):1774–1782. DOI: 10.1161/CIRCULATIONAHA.111.037283. PMID: 22007100.
Article
5. Hung MJ, Hu P, Hung MY. Coronary artery spasm: review and update. Int J Med Sci. 2014; 11(11):1161–1171. DOI: 10.7150/ijms.9623. PMID: 25249785. PMCID: PMC4166862.
Article
6. Kusama Y, Kodani E, Nakagomi A, Otsuka T, Atarashi H, Kishida H, et al. Variant angina and coronary artery spasm: the clinical spectrum, pathophysiology, and management. J Nippon Med Sch. 2011; 78(1):4–12. DOI: 10.1272/jnms.78.4. PMID: 21389642.
Article
7. Yasue H, Nakagawa H, Itoh T, Harada E, Mizuno Y. Coronary artery spasm—clinical features, diagnosis, pathogenesis, and treatment. J Cardiol. 2008; 51(1):2–17. DOI: 10.1016/j.jjcc.2008.01.001. PMID: 18522770.
Article
8. Hashimoto Y, Matsuda Y, Enomoto Y, Inoue H, Arai T, Saitoh T, et al. Case of undiagnosed vasospastic angina first noted during anesthesia. Masui Jpn J Anesthesiol. 2009; 58(4):484–487.
9. Chung J, Gong HY, Park J, Yoo SH, Kim NS, Jung HS, et al. Coronary artery spasm induced by carotid sinus stimulation during arthroscopic shoulder surgery: a case report. Medicine (Baltimore). 2019; 98(5):e14352. DOI: 10.1097/MD.0000000000014352. PMID: 30702625. PMCID: PMC6380765.
10. Adachi N, Miyamoto Y, Hodono S, Yorozuya T, Arai T. Management of unexpected coronary artery spasm in an asymptomatic patient during anaesthesia. Acta Anaesthesiol Scand. 2003; 47(9):1172–1173. DOI: 10.1034/j.1399-6576.2003.00216.x. PMID: 12969114.
Article
11. Crea F, Chierchia S, Kaski JC, Davies GJ, Margonato A, Miran DO, et al. Provocation of coronary spasm by dopamine in patients with active variant angina pectoris. Circulation. 1986; 74(2):262–269. DOI: 10.1161/01.CIR.74.2.262. PMID: 3731418.
Article
12. Doyle DJ, Mark PWS. Reflex bradycardia during surgery. Can J Anaesth. 1990; 37(2):219–222. DOI: 10.1007/BF03005473. PMID: 2088315.
Article
13. Hirata N, Miyashita R, Maruyama D, Kawaguchi R, Shimizu H, Yamakage M. Heart rate variability during abdominal surgical manipulation under general and epidural anesthesia. J Anesth. 2012; 26(6):900–904. DOI: 10.1007/s00540-012-1431-5. PMID: 22718015.
Article
14. Yasue H, Touyama M, Shimamoto M, Kato H, Tanaka S, Akiyama F. Role of autonomic nervous system in the pathogenesis of prinzmetal’s variant form of Angina. Circulation. 1974; 50(3):534–539. DOI: 10.1161/01.CIR.50.3.534. PMID: 4415644.
Article
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