J Korean Ster Func Neurosurg.
2021 Sep;17(2):103-109. 10.52662/jksfn.2021.00046.
Consecutively occurring radiation-induced meningiomas with various pathologic diagnoses: a case report
- Affiliations
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- 1Department of Neurosurgery and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea
- 2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
- KMID: 2534580
- DOI: http://doi.org/10.52662/jksfn.2021.00046
Abstract
- Meningioma is the second most common type of radiation-induced neoplasia that occurs after cranial radiotherapy. In this paper, we report a case of multiple radiation-induced meningiomas (RIMs) with different pathologies. A 23-year-old woman had a medical history of medulloblastoma at 2 years of age, for which she received chemotherapy and radiotherapy after operation. On follow-up magnetic resonance imaging (MRI) performed at the age of 13 years, RIM was observed in the left sphenoid ridge. The meningioma was treated with surgery and Gamma Knife radiosurgery. On follow-up MRI performed at 21 years of age, another RIM was found in the right temporal dura. The second RIM was stable after Gamma Knife surgery, but a third RIM occurred in front of the second. We removed the second and third RIMs in one operation. The pathological diagnoses of the first, second, and third RIMs were transitional, meningothelial, and atypical meningothelial meningioma, respectively. As shown in this case, RIM can develop several decades after exposure to radiation, and various grades of meningioma can occur at multiple sites. Therefore, patients who have undergone radiotherapy should receive long-term follow-up to check for RIM, and the appropriate treatment should be administered for the expected grade.
