Nat Prod Sci.  2022 Sep;28(3):115-120. 10.20307/nps.2022.28.3.115.

Cytotoxic Neoflavonoids and Chalcones from the Heartwood of Dalbergia melanoxylon

• Chung HS

• KMID: 2534103
• DOI: http://doi.org/10.20307/nps.2022.28.3.115

Abstract

Ten compounds, consisting of neoflavonoids (1-5), isoflavonoids (6 and 7), flavanone (8), and chalcones (9 and 10) were isolated from the ethyl acetate and n-butanol-soluble fractions of the heartwood of Dalbergia melanoxylon. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. Compounds 1-10 were evaluated for cytotoxicity against HCT116 human colorectal cancer, MDA-MB-231 human metastatic breast cancer, and A2058 human melanoma cell lines. Among them, compounds 3 and 10 showed the strongest cytotoxic activity with IC ₅₀ values of 11.92 ± 1.07 μM, 10.83 ± 1.02 μM, and 14.37 ± 1.02 μM, 13.62 ± 1.09 μM against HCT116 and MDA-MB-231 cell lines, respectively. Compounds 9 and 10 also had cytotoxic activity with IC 50 values of 13.49 ± 1.18 μM and 9.82 ± 0.91 μM against A2058 cell lines, respectively. To the best our knowledge, compounds 2 and 5-10 were isolated from this source for the first time.

Keyword

Dalbergia melanoxylon; heartwood; HCT116; MDA-MB-231; A2058; neoflavonoid; chalcone