J Korean Ophthalmol Soc.  2022 Sep;63(9):769-777. 10.3341/jkos.2022.63.9.769.

Short-term Outcomes and Prognostic Factor of Cataract Combined Surgery with iStent Inject versus XEN

• Ma GJ
• Hwang HB
• Yim HB
• Kim YC

• KMID: 2533723
• DOI: http://doi.org/10.3341/jkos.2022.63.9.769

Abstract

Purpose
To analyze the intraocular pressure (IOP) lowering effect, prognostic factors, and complications that occurred after iStent inject^® or XEN^® implantation in South Korea.
Methods
We retrospectively analyzed 83 eyes with glaucoma who were followed-up for more than 6 months after iStent inject^® or XEN^® implantation alone or combination with cataract surgery. The success of surgery was defined as an IOP ≤21 mmHg and IOP reduction ≥20% from preoperative IOP.
Results
The average IOP drop rate for 6 months after surgery was 33.80% for iStent inject^® (group A, 24 eyes), 24.91% for XEN^® (group B, 15 eyes), 20.47% for combined iStent inject^® and cataract surgery (group A-1, 32 eyes), and 30.39% for combined XEN^® and cataract surgery. The cumulative success rate of 6 months after surgery was 45.5% ± 11.2% for group A, 52.8% ± 15.4% for group B, 51.9% ± 9.0% for group A-1, and 83.3% ± 10.8% for group B-1. The difference in success rates between groups A and B was not statistically significant (p = 0.574), and also between groups A-1 and B-1 (p = 0.079).
Conclusions
iStent inject^® and XEN^® both have a significant effect on lowering IOP, regardless of combining cataract surgery. XEN^® implantation led to a statistically significant reduction in IOP lowering medications.

Keyword

Glaucoma; Intraocular pressure; IStent inject; XEN gel implant