Med Lasers.  2021 Sep;10(3):138-145. 10.25289/ML.2021.10.3.138.

Decade Long Survey of Low-level Laser Therapy/ Photobiomodulation (LLLT/PBM) Therapy for Oral Mucositis Treatment

• Ryu HS
• Abueva C
• Chung PS
• Woo SH

• KMID: 2533520
• DOI: http://doi.org/10.25289/ML.2021.10.3.138

Abstract

Low-level laser therapy or photobiomodulation (LLLT/PBM) therapy has been widely applied to enhance and accelerate the recovery of oral mucositis. This study investigates the documented effect of LLLT on oral mucositis caused by chemotherapy. This review appraises 6 animal studies and 12 clinical studies published in the Pubmed database during the past 10 years, related to the application of LLLT for the treatment of mucositis. Despite varied parameters and diverse conditions, the assessed articles indicate that application of LLLT on oral mucositis using near-infrared wavelengths is prophylactic, reduces pain, and enables a rapid recovery. Various combined treatments were also identified among the published papers, which further establishes the efficacy of LLLT as a viable treatment.

Keyword

Oral mucositis; Low-level laser therapy; Photobiomodulation therapy; Chemotherapy