J Korean Assoc Oral Maxillofac Surg.  2022 Aug;48(4):192-200. 10.5125/jkaoms.2022.48.4.192.

Treatment outcomes and prognostic factors in oral tongue cancer: a 20-year retrospective study at the National Cancer Center, South Korea

• Kim MG
• Choi YS
• Youn SM
• Ko JH
• Oh HJ
• Lee JH
• Park JY
• Choi SW

• KMID: 2532816
• DOI: http://doi.org/10.5125/jkaoms.2022.48.4.192

Abstract

Objectives
This study aimed to analyze the treatment outcomes and to evaluate the clinicopathological prognostic factors of oral tongue cancer.
Patients and Methods
We retrospectively analyzed treatment results and prognostic factors in 205 patients with oral tongue squamous cell carcinoma who were admitted to the National Cancer Center, South Korea, between January 2001 and December 2020. The patients were treated with surgery and postoperative, definitive radiotherapy (RT) or chemoradiotherapy (CRT).
Results
Eighteen patients (8.8%) were treated with curative RT or CRT, while the rest (91.2%) were treated with surgery with or without postoperative RT or CRT. The median follow-up period was 30 months (range, 0-234 months). The 5-year overall survival (OS) and 5-year disease-free survival (DFS) were 72% and 63%, respectively. Multivariate analysis revealed that a positive neck nodal status (N1, N2-3) was significantly associated with poorer 5-year OS and DFS, while perineural invasion was associated with poorer 5-year DFS.
Conclusion
Cervical metastasis and perineural invasion are significant prognostic predictors, and combination treatments are necessary for improving OS and DFS in patients with these factors.

Keyword

Tongue; Oral cancer; Treatment outcome; Prognostic factors

Figure

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  Fig. 1 Kaplan–Meier curve of overall survival.

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  Fig. 2 Kaplan–Meier curve of overall survival by neck status.

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  Fig. 3 Kaplan–Meier curve of overall disease-free survival.

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  Fig. 4 Kaplan–Meier curve of disease-free survival by neck status.

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  Fig. 5 Kaplan–Meier curve of disease-free survival by presence of perineural invasion (PNI).

Reference

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