Korean J Blood Transfus.  2022 Aug;33(2):107-113. 10.17945/kjbt.2022.33.2.1 0 7.

Three Cases of SARS-CoV-2 Infection with Cold Antibody of Undetermined Specificity in Antibody Screening in Transfusion Labs

• Kim BJ
• Shin DW
• Hong YJ
• Kim H
• Park KU

• KMID: 2532794
• DOI: http://doi.org/10.17945/kjbt.2022.33.2.1 0 7

Abstract

SARS-CoV-2 infections continue to occur in this worldwide pandemic and have been associated with various symptoms, including autoimmune disorders. Of the latter, several reports of SARS-CoV-2-associated cold-agglutinin syndrome (CAS) have been published. CAS is associated with other viral infections, such as that by the Epstein–Barr virus. This paper reports a case series of SARS-CoV-2-associated cold-agglutinin syndrome presenting as an antibody of undetermined specificity mainly reactive at cold temperatures and mostly detected as C3d, but sometimes as IgM on the direct antiglobulin test.

Keyword

Cold agglutinin disease; SARS-CoV-2; Autoantibody