J Korean Soc Radiol.  2022 Jul;83(4):931-937. 10.3348/jksr.2021.0143.

Diffuse Large B-Cell Lymphoma Associated with a Chronic Inflammatory Condition Induced by Metallic Implants: A Case Report

  • 1Department of Radiology, College of Medicine, Inje University, Busan Paik Hospital, Busan, Korea


Chronic inflammatory condition associated with metallic implant insertion is a risk factor for diffuse large B-cell lymphoma (DLBCL). Metal ions play a role in the pathogenesis of lymphoma. We report a rare case of DLBCL in a patient who had a metallic implant in the proximal tibia for 15 months. Radiologic studies, including US and MRI, showed disproportionately large extraosseous soft-tissue mass and bone marrow involvement without prominent bone destruction. Multiple complications are associated with metallic implants, and misdiagnosis may lead to inappropriate treatment. Therefore, distinguishing lymphomas caused by a metallic implant-induced chronic inflammatory condition from other periprosthetic benign lesions and malignant soft tissue masses is challenging, but it is critical.


Prostheses and Implants; Diffuse Large B-Cell Lymphoma; Magnetic Resonance Imaging; Ultrasonography
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