Korean J Clin Oncol.  2022 Jun;18(1):36-46. 10.14216/kjco.22005.

Local complications are related to poor long-term outcome in patients undergoing curative gastrectomy for advanced gastric cancer

• Ha TS
• Cho GS
• Shin EJ
• Ryu SW
• Ryu KW
• Kim MC
• Hyung WJ
• Kim CY
• Lee HJ
• Shin DW
• Lee JH

• KMID: 2531835
• DOI: http://doi.org/10.14216/kjco.22005

Abstract

Purpose
The present study was performed to investigate the effects of local complications (LC) on long-term survival and cancer recurrence in patients undergoing curative gastrectomy for gastric cancer.
Methods
We analyzed 2,627 patients after curative gastrectomy for gastric cancer between January 2001 and December 2006. Patients were classified into groups no complications (NC), LC, or systemic complications (SC).
Results
Among the 2,627 patients, 475 patients developed complications (LC group [n=374, 14.2%] and SC group [n=101, 3.9%]). The 5-year cancer-specific survival rate was significantly poorer in the LC group compared to the NC and SC groups (LC, 78.0%; NC, 85.4%; SC, 80.2%; P=0.007). The occurrence of LC was identified as a significant independent prognostic factor for overall and cancer-specific survival (hazard ratio [HR], 2.08; 95% confidence interval [CI], 1.46–2.97; P=0.001 and HR, 1.77; 95% CI, 1.12–2.81; P=0.015). The tumor recurrence rates were higher in the LC group than the in other two groups (LC, 23.5%; NC, 15.4%; SC, 15.8%; P<0.001). The occurrence of LC was an independent predictor of tumor recurrence in patients undergoing curative gastrectomy for gastric cancer (HR, 1.55; 95% CI, 1.11–2.17; P=0.011).
Conclusion
LC are associated with adverse long-term outcomes in patients after curative gastrectomy for advanced gastric cancer.

Keyword

Stomach neoplasms; Postoperative complication; Tumor recurrence