Ann Pediatr Endocrinol Metab.  2022 Jun;27(2):81-82. 10.6065/apem.2222057edi01.

Commentary on "Classic and backdoor pathways of androgen biosynthesis in human sexual development"

• Jeong HR

• KMID: 2531270
• DOI: http://doi.org/10.6065/apem.2222057edi01

Reference

References

1. Miller WL. Steroidogenic electron-transfer factors and their diseases. Ann Pediatr Endocrinol Metab. 2021; 26:138–48.

2. Wilson JD. Sexual differentiation. Annu Rev Physiol. 1978; 40:279–306.

3. Miller WL, Auchus RJ. The "backdoor pathway" of androgen synthesis in human male sexual development. PLoS Biol. 2019; 17:e3000198.

4. Wilson JD, Auchus RJ, Leihy MW, Guryev OL, Estabrook RW, Osborn SM, et al. 5alpha-androstane-3alpha,17beta-diol is formed in tammar wallaby pouch young testes by a pathway involving 5alpha-pregnane-3alpha,17alpha-diol-20-one as a key intermediate. Endocrinology. 2003; 144:575–80.

5. O'Shaughnessy PJ, Antignac JP, Le Bizec B, Morvan ML, Svechnikov K, Söder O, et al. Alternative (backdoor) androgen production and masculinization in the human fetus. PLoS Biol. 2019; 17:e3000002.

6. Biason-Lauber A, Miller WL, Pandey AV, Flück CE. Of marsupials and men: "Backdoor" dihydrotestosterone synthesis in male sexual differentiation. Mol Cell Endocrinol. 2013; 371:124–32.

7. Lee HG, Kim CJ. Classic and backdoor pathways of androgen biosynthesis in human sexual development. Ann Pediatr Endocrinol Metab. 2022; 27:83–9.