Int J Arrhythm.
2022 Jun;23(2):9. 10.1186/s42444-022-00060-4.
Optogenetics in cardiology: methodology and future applications
- Affiliations
-
- 1Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
- 2Department of Electrical Engineering, California Insti‑ tute of Technology, Pasadena, CA, USA
- 3Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA
- 4Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan.
- 5Cardiovascular Center, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan
- 6College of Medicine, National Taiwan University, Taipei, Taiwan
- 7Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, 30010 Hsinchu, Taiwan
- 8Present Address: Hsinchu, Taiwan.
- KMID: 2530964
- DOI: http://doi.org/10.1186/s42444-022-00060-4
Abstract
- Optogenetics is an emerging biological approach with the unique capability of specific targeting due to the precise light control with high spatial and temporal resolution. It uses selected light wavelengths to control and modulate the biological functions of cells, tissues, and organ levels. Optogenetics has been instrumental in different biomedical applications, including neuroscience, diabetes, and mitochondria, based on distinctive optical biomedical effects with light modulation. Nowadays, optogenetics in cardiology is rapidly evolving for the understanding and treatment of cardiovascular diseases. Several in vitro and in vivo research for cardiac optogenetics demonstrated visible progress. The optogenetics technique can be applied to address critical cardiovascular problems such as heart failure and arrhythmia. To this end, this paper reviews cardiac electrophysiology and the technical progress about experimental and clinical cardiac optogenetics and provides the background and evolution of cardiac optogenetics. We reviewed the literature to demonstrate the servo type, transfection efficiency, signal recording, and heart disease targets in optogenetic applications. Such literature review would hopefully expedite the progress of optogenetics in cardiology and further expect to translate into the clinical terminal in the future.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The Rise of On-Demand Research and Specific Applications: Optogenetics in Urology
- Optogenetics Applications for Treating Spinal Cord Injury
- Optogenetic neuromodulation with gamma oscillation as a new strategy for Alzheimer disease: a narrative review
- Optogenetic and Chemogenetic Approaches for Studying Astrocytes and Gliotransmitters
- Reflection on Nursing Methodology
