Nat Prod Sci.
2022 Jun;28(2):62-67. 10.20307/nps.2022.28.2.62.
Chemical Profile and Cytotoxicity Activity of Stem-bark of Anacardium occidentale
- Affiliations
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- 1Department of Chemistry, Faculty of Science, Federal University Lokoja, Lokoja, Kogi state, Nigeria
- 2Centre for Natural Products and Traditional Knowledge, Indian Institute of Chemical Technology, Hyderabad, India
- 3Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad, India
- 4Department of Industrial Chemistry, Faculty of Physical Sciences, University of Ilorin, Ilorin, Nigeria
- KMID: 2530933
- DOI: http://doi.org/10.20307/nps.2022.28.2.62
Abstract
- Column chromatographic fractionation of the methanol and ethyl acetate extracts of the stem-bark of Anacardium occidentale led to the isolation of five compounds (1-5). Their structures were determined by spectroscopic means by comparing spectral data to be β-sitosterol (1), 2,4-dihydroxy acetophenone (2), 1-monolinolein (3), ethyl oleate (4) and β-sitosterol-3-O-β-D-glucopyranoside (5). These compounds were evaluated for cytotoxicity against human cancer cell lines: A549, SCOV3 and rat normal cell line NRK49f. Compounds 2-5 were for the first time isolated from A. occidentale.
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