Investig Clin Urol.  2022 Jul;63(4):407-414. 10.4111/icu.20210459.

Low serum total testosterone level as a predictor of upgrading in low-risk prostate cancer patients after radical prostatectomy: A systematic review and meta-analysis

• Gan S
• Liu J
• Chen Z
• Xiang S
• Gu C
• Li S
• Wang S

• KMID: 2530909
• DOI: http://doi.org/10.4111/icu.20210459

Abstract

Purpose
To investigated the association between serum total testosterone and Gleason score upgrading of low-risk prostate cancer after radical prostatectomy (RP).
Materials and Methods
Medline, Web of Science, Embase, and Cochrane Library databases were searched to identify eligible studies published before October 2021. Multivariate adjusted odds ratios (ORs) and associated 95% confidence intervals (CIs) were calculated using random or fixed effects models.
Results
Five studies comprising 1,203 low-risk prostate cancer patients were included. The results showed that low serum total testosterone (<300 ng/dL) is associated with a high rate of Gleason score upgrading after RP (OR, 2.3; 95% CI, 1.38–3.83; p<0.001; I 2 , 92.2%). Notably, sensitivity and meta-regression analyses further strengthen the reliability of our results.
Conclusions
Our results support the idea that low serum total testosterone is associated with a high rate of Gleason score upgrading in prostate cancer patients after RP. It is beneficial for urologist to ensure close monitoring of prostate-specific antigen levels and imaging examination when choosing non-RP treatment for low-risk prostate cancer patients.

Keyword

Meta-analysis; Prostatectomy; Prostatic neoplasms; Testosterone