J Korean Med Sci.  2015 Mar;30(3):317-322. 10.3346/jkms.2015.30.3.317.

Comparison of Pathological and Biochemical Outcomes after Radical Prostatectomy in Korean Patients with Serum PSA Ranges

• Lee HW
• Jeon HG
• Jeong BC
• Seo SI
• Jeon SS
• Choi HY
• Lee HM

• KMID: 2133311
• DOI: http://doi.org/10.3346/jkms.2015.30.3.317

Abstract

The aim of this study was to assess surgical outcome at radical prostatectomy (RP) in Korean men with a serum prostate-specific antigen (PSA) level of 2.5 to 3.0 ng/mL and compared with those of patients who had a PSA level of 3.0-4.0 and 4.0-10.0 ng/mL. We retrospectively compared clinico-pathological characteristics and biochemical recurrence (BCR) risk in patients with PSA level of 2.5-3.0 (group 1, n = 92, 5.7%), 3.0-4.0 (group 2, n = 283, 17.5%), or 4.0-10.0 ng/mL (group 3, n = 1,242, 76.8%) who underwent RP between 1995 and 2013. The pathologic characteristics including Gleason score, pathologic stage, and percentage of significant cancer in group 1 were similar to those in group 2 and group 3. Furthermore, pathological upgrading and upstaging were found in 23 (30.7%) and 10 (14.7%) in group 1, 84 (33.9%) and 19 (8.8%) in group 2, and 321 (32.8%) and 113 (12.8%) in group 3, respectively, with no significant differences among the three groups (all P > 0.05). In multivariate analysis, PSA grouping was not an independent predictor of BCR. Within the population with PSA lower than 10 ng/mL, substratification of PSA is not a significant predictor for upgrading, upstaging, or adverse prognosis.

Keyword

Prostatic Neoplasms; Prostate Biopsy; Radical Prostatectomy; Upgrading; Upstaging

MeSH Terms

Aged
Disease-Free Survival
Humans
Male
Middle Aged
Neoplasm Recurrence, Local/*pathology
Neoplasm Staging
Prostate/*pathology/surgery
Prostate-Specific Antigen/*blood
*Prostatectomy
Prostatic Neoplasms/*pathology/surgery
Republic of Korea
Retrospective Studies
Treatment Outcome
Prostate-Specific Antigen

Figure

• 

  Fig. 1 Kaplan-Meier estimates of biochemical recurrence (BCR)-free survival (BFS) according to preoperative PSA are shown.

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