Blood Res.  2022 Jun;57(2):161-164. 10.5045/br.2022.2022059.

A rare case of primary plasma cell leukemia exhibiting the small-cell variant of plasma cells

• Kim JA
• Shin WY
• Kim J
• Bang HI
• Yoon SY
• Park R

• KMID: 2530884
• DOI: http://doi.org/10.5045/br.2022.2022059

Figure

• 

  Fig. 1 Microscopic findings and FISH analysis of the small-cell type of plasma cell leukemia. Peripheral blood and bone marrow aspirate smears: small-cell type neoplastic plasma cells and atypical multinu-clear plasma cells (A), peripheral blood, Wright–Giemsa stain, ×400; (B), bone marrow, Wright–Giemsa stain, ×400; (C, D) bone marrow, Wright–Giemsa stain, ×1,000. (E) FISH analysis showing an IGH/ CCND1 rearrangement and p53 (17p) deletion (white arrow). Abbreviation: FISH, fluorescence in situ hybridization.

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  Fig. 2 Flow-cytometric immunophenotyping of the small-cell type of plasma cell leukemia. Clonal plasma cells in the bone marrow exhibited a CD19-/CD20+/CD38+/CD56-/CD138+ phenotype and cytoplasmic lambda light-chain restriction gated by CD45- and low side scatter.

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