J Korean Acad Oral Health.  2022 Jun;46(2):63-69. 10.11149/jkaoh.2022.46.2.63.

Preventive effect of dentifrice containing 1,450 ppm fluoride and sodium pyrophosphate

• Park MJ
• Cho JW
• Yoo HJ
• Yun MH
• Shin KH
• Park YH

• KMID: 2530814
• DOI: http://doi.org/10.11149/jkaoh.2022.46.2.63

Abstract

Objectives
This study aimed to evaluate the effects of a toothpaste containing sodium pyrophosphate and a high concentration (1,450 ppm) of fluoride on dental plaque, gingivitis index, and calculus index in a clinical trial.
Methods
This study used an eight-week, randomized, double-blinded, controlled, comparative, parallel design. The participants, who voluntarily signed a consent form, were screened through visit evaluation if they met the selection/exclusion criteria. After a one-week run-in period, the selected participants were randomly assigned to either an experimental or control group in the order of their enrollment. Subsequently, the participants were asked to brush their teeth with the study toothpaste using the rolling method for 3 min, thrice daily, for 8 weeks. Oral examinations were performed at baseline and after 3 weeks, 4 weeks, and 8 weeks. Evaluation of papillary marginal attachment index (PMA index), Talbott’s gingival index, patient hygiene performance index (PHP index), Turesky plaque index, and calculus index were performed during the oral examination.
Results
After 8 weeks, the PMA indices were 7.12 for the control group and 5.00 for experimental groups. In addition, the PHP index was 2.06 for the control group and 1.66 for the experimental group. Significant differences were observed between the control and experimental groups in all indice (P<0.05).
Conclusions
This study shows that using a toothpaste containing sodium fluoride, sodium pyrophosphate, tocopherol acetate, and dental-type silica improves dental plaque removal, reduces gingivitis, and inhibits calculus formation.

Keyword

Dentifrices; Fluorides; Gingivitis; Sodium pyrophosphate

Reference

References

1. Choi JO, Nam SH. 2014; Change in surface of primary tooth using different type of toothpaste. J Korean Soc Dent Hyg. 14:281–286. DOI: 10.13065/jksdh.2014.14.02.281.

2. Ma DS, Park DY, Paik DI, Moon HS, Kim JB. 1998; A clinical study of toothpaste containing pyrophosphate, hydroxyapatite and Vitamin-E on the prevention of calculus formation and gingivitis. J Korean Acad Dent Health. 22:13–18.

3. Han YS, Lee JE, Moon HJ, Lim SR, Cho YS. 2015; An Analysis on the Purchase Satisfaction, Repurchase Intention and Recommendation according Toothpaste Choice Standard. J Dent Hyg Sci. 15:77–82. DOI: 10.17135/jdhs.2015.15.1.77.

4. Park NK, Song JH. 2018; Evaluation of Total and Soluble Fluoride Concentrations in Ten Toothpastes for Children. J Korean Acad Pediatr Dent. 45:235–241. DOI: 10.5933/JKAPD.2018.45.2.235.

5. Wright JT, Hanson N, Ristic H, Whall CW, Estrich CG, Zentz RR. 2014; Fluoride toothpaste efficacy and safety in children younger than 6 years. J Am Dent Assoc. 145:182–189. DOI: 10.14219/jada.2013.37. PMID: 24487610. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84899689497&origin=inward.

6. Twetman S, Axelsson S, Dahlgren H, Holm AK, Kallestal C, Lagerlof F, Lingstrom P, Mejare I, Nordenram G, Norlund A. 2003; Caries-preventive effect of fluoride toothpaste: a systematic review. Acta Odontol Scand. 61:347–355. DOI: 10.1080/00016350310007590. PMID: 14960006. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=9144256045&origin=inward.

7. Jeong IS, Kim JH, Yun KD. 2020; Antimicrobial activity of dental polishing bur material with fluoride ion. J Prosthet Dent. 58:201–206. DOI: 10.4047/jkap.2020.58.3.201.

8. Kim JC. 1995; Protection of dental caries and fluoride. J Korean Dent Assoc. 33:18–21.

9. Park KK, Kim WK. 2000; Prospective on Prevention of Dental Caries and Water Fluoridation. J Korean Dent Assoc. 38:86–93.

10. Conti AJ, Lotzkar S, Daley R, Cancro L, Marks RG, McNeal DR. 1988; A 3-year clinical trial to compare efficacy of dentifrices containing 1.14% and 0.76% sodium monofluorophosphate. Community Dent Oral Epidemiol. 16:135–138. DOI: 10.1111/j.1600-0528.1988.tb00560.x. PMID: 3288434. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0024024326&origin=inward.

11. O'mullane DM, Kavanagh D, Ellwood RP, Chesters RK, Schafer F, Huntington E, Jones PR. 1997; A Three-year Clinical Trial of a Combination of Trimetaphosphate and Sodium Fluoride in Silica Toothpastes. J Dent Res. 76:1776–1781. DOI: 10.1177/00220345970760110901. PMID: 9372795. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0031280390&origin=inward.

12. Europäische Kommission Scientific Committee on Cosmetic Products and Non-Food Products. 2003. Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers: The safety of fluorine compounds in oral hygiene products for children under age of 6 years. SCCNFP 24th plenary meeting. p. 1–26.

13. Kim AO, Jeong SS, Kim DE, Ha WH, Moon KT, Choi CH, Hong SJ. 2016; Remineralisation effect of 1,500 ppm fluoride-containing toothpaste in enamel early caries lesion. J Korean Acad Oral Health. 40:270–276. DOI: 10.11149/jkaoh.2016.40.4.270.

14. Ministry of Food and Drug Safety. 2014. Medicines etc Standard manufacturing standards Some revision notices(014-152). Ministry of Food and Drug Safety;Cheongju: p. 1–9. DOI: 10.11149/jkaoh.2016.40.4.270.

15. White DJ. 1988; Reactivity of fluoride dentifrices with artificial caries II. Effect on subsurface lesions: F uptake, F distribution, surface hardening and remineralization. Caries Res. 22:27–36. DOI: 10.1159/000261079. PMID: 3422058. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0023799017&origin=inward.

16. Saeki Y, Kato T, Okuda K. 1996; Inhibitory effects of funoran on the adherence and colonization of oral bacteria. Bull Tokyo Dent Coll. 37:77–92. PMID: 9151580. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0030132661&origin=inward.

17. Lee YJ, Park WH. 1999; Effects of α-Tocopherol Acetate on Puromycin Aminonucleoside-Induced Glomerular Injury in Spontaneously Hypertensive Rats. Biomedical Science Letters. 5:75–84. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0030132661&origin=inward.

18. Jung HK, Chung SY, Ahn YS, Shin KH, Cho JW. 2020; The effect of dentifrice including dental type silica, tocopherol acetate, sodium fluoride and sodium pyrophosphate on mineral density in enamel. J Korean Acad Oral Health. 44:180–186. DOI: 10.11149/jkaoh.2020.44.4.180.

19. Schäfer F, Adams SE, Nicholson JA, Cox TF, McGrady M, Moore F. 2007; In vivo evaluation of an oral health toothpaste with 0.1% vitamin E acetate and 0.5% sunflower oil (with vitamin F). International Dental Journal. 57(S2):119–123. DOI: 10.1111/j.1875-595X.2007.tb00152.x. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34247365504&origin=inward.

20. Public Oral Health Textbook Development Committee. 2014. Public oral health. 3th ed. Gomoonsa;Seoul: p. 436–437. DOI: 10.1111/j.1875-595x.2007.tb00152.x. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34247365504&origin=inward.

21. Talbott K, Mandel ID, Chilton NW. 1977; Reduction of baseline gingivitis scores with repeated prophylaxes. J Prev Dent. 4:28–29. PMID: 275491. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0017550986&origin=inward.

22. Manhold JH, Volpe AR, Parker L, Adams SH. 1965; In vivo calculus assessment. II. A comparison of scoring techniques. J Periodontol. 36:299–304. DOI: 10.1902/jop.1965.36.4.299. PMID: 14326696.

23. Kim SA, Kim KS, Kim MJ, et al. 2016. Contemporary Preventive Dentistry. 2th ed. Daehan Narae;Seoul: p. 101–102. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0017550986&origin=inward.

24. Turesky S, Gilmore ND, Glickman I. 1970; Reduced plaque formation by the choloromethy l analogue of vitamine C. J Periodontal. 41:41–43. DOI: 10.1902/jop.1970.41.41.41. PMID: 5264376.

25. Shani Ann Mani. 2009; Evidence-based clinical recommendation for fluoride use : a review. Arch Orofac Sci. 4. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0017550986&origin=inward.

26. Herschel S. 2003; Horowitz DOS, MPH. The 2001 CDC recommendations for using fluoride to prevent and control dental caries in the United States. J Public Health Dent. 63:3–8. DOI: 10.1111/j.1752-7325.2003.tb03467.x. PMID: 12597580. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=4444383976&origin=inward.

27. Feng Y, Yin W, Hu D, Zhang Y, Ellwood R.P, Pretty I.A. 2007; Assessment of Autofluorescence to Detect the Remineralization Capabilities of Sodium Fluoride, Monofluorophosphate and Non-Fluoride Dentifrices. Caries Res. 41:358–364. DOI: 10.1159/000104793. PMID: 17713335. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34548165780&origin=inward.

28. Mittal M, Flora SJS. 2006; Effects of individual and combined exposure to sodium arsenite and sodium fluoride on tissue oxidative stress, arsenic and fluoride levels in male mice, Chem. Biol Interact. 162:128–139. DOI: 10.1016/j.cbi.2006.05.018. PMID: 16828073. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33746868282&origin=inward.

29. Kim JH, Jeong SS, Choi CH, Hong SJ. 2006; Fluoride concentration of commercial dentifrices and effect of fluoride containing dentifrices on artificial enamel caries. J Korean Acad Dent Health. 30:55–66. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0017550986&origin=inward.

30. Philpotts CJ, Harding CR, Carlile Dr.MJ, Sadler CJ, Wright J. 2007; Ex vivo delivery and penetration of α-tocopherol acetate and linoleic acid to gingival tissue from a toothpaste formulation. International Dental Journal. 57:129–134. DOI: 10.1111/j.1875-595X.2007.tb00154.x. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34247347449&origin=inward.

31. Hong JY, Lee JS, Choi SH, Shin HS, Park JC, Shin SI, Chung JH. 2019; A randomized, double-blind, placebocontrolled multicenter study for evaluating the effects of fixed-dose combinations of vitamin C, vitamin E, lysozyme, and carbazochrome on gingival inflammation in chronic periodontitis patients. BMC Oral Health. 19:2–8. DOI: 10.1186/s12903-019-0728-2. PMID: 30845920. PMCID: PMC6407240. PMID: 447f87172388441e8c5df5820d1442e7. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85062594733&origin=inward.

32. JBrading MG, Beasley T, Evans M, Gibson C, Lloyd A, Schafer F, Whittaker J. 2009; Gum health benefits of a silica based fluoride toothpaste containing zinc citrate, potassium citrate, hydroxyapatite and vitamin E acetate. International Dental Joumal. 59:332–237. DOI: 10.1002/idj.2009.59.6s1.332.

33. Kim BJ, Kim JH, Ha WH, Ahn JH. 2013; A Study of Toothpaste Containing Pyrophosphates and Cellulose on the Abrasivity and Cleaning Power. J Dent Hyg Sci. 13:83–90. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0017550986&origin=inward.

34. Lobene RR. 1986; A clinical study of the anticalculus effect of a dentifrice containing soluble pyrophosphate and sodium fluoride. Clin Prev Dent. 8:5–7. PMID: 3015475. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0022713113&origin=inward.

35. Kim JB, Paik DI, Moon HS, Ma DS. 1989; A clinical comparison of the anticalculus effect of two kinds of therapeutic dentifrice. J Korean Acad Oral Health. 13:7–16. PMID: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0022713113&origin=inward.