Korean J Otorhinolaryngol-Head Neck Surg.  2022 Jun;65(6):358-361. 10.3342/kjorl-hns.2021.00738.

A Case of Neuromyelitis Optica Spectrum Disorder of a Patient Who Present for Fungal Sinusitis

• Seo JW
• Jeong DY
• Kim H
• Choi JY

• KMID: 2530604
• DOI: http://doi.org/10.3342/kjorl-hns.2021.00738

Abstract

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system, characterized by repeatedly invading the brain, optic nerve, or spinal cord. In 2004, when a disease-specific antibody (aquaporin-4-immunoglobulin G) was discovered in the serum of an optic neuromyelitis patient, it was thought to be a separated disease from multiple sclerosis. Since 2004, however, the concept of the disease has been expanded to include NMO spectrum disorder (NMOSD). We experienced a rare case of NMOSD in a patient who presented with left visual disturbance and underwent endoscopic sinus surgery because of acute fungal sinusitis. We report this case with a review of the literature.

Keyword

Anti-aquaporin 4 autoantibody; Fungal; Neuromyelitis optica; Optic neuritis; Sinusitis