Diabetes Metab J.  2022 May;46(3):414-416. 10.4093/dmj.2022.0089.

Implication of Sex Differences in Visceral Fat for the Assessment of Incidence Risk of Type 2 Diabetes Mellitus

• Ju SH
• Yi HS

• KMID: 2530180
• DOI: http://doi.org/10.4093/dmj.2022.0089

Reference

1. Korean Diabetes Association. Diabetes fact sheet 2020. Seoul: Korean Diabetes Association;2020.

2. Freemantle N, Holmes J, Hockey A, Kumar S. How strong is the association between abdominal obesity and the incidence of type 2 diabetes? Int J Clin Pract. 2008; 62:1391–6.

3. Zhang M, Hu T, Zhang S, Zhou L. Associations of different adipose tissue depots with insulin resistance: a systematic review and meta-analysis of observational studies. Sci Rep. 2015; 5:18495.

4. Frank AP, de Souza Santos R, Palmer BF, Clegg DJ. Determinants of body fat distribution in humans may provide insight about obesity-related health risks. J Lipid Res. 2019; 60:1710–9.

5. Romanski SA, Nelson RM, Jensen MD. Meal fatty acid uptake in adipose tissue: gender effects in nonobese humans. Am J Physiol Endocrinol Metab. 2000; 279:E455–62.

6. Tremollieres FA, Pouilles JM, Ribot CA. Relative influence of age and menopause on total and regional body composition changes in postmenopausal women. Am J Obstet Gynecol. 1996; 175:1594–600.

7. Lee YS, Lee HJ, Oh JY, Hong YS, Sung YA. Sex hormone binding globulin, body fat distribution and insulin resistance in premenopausal women. J Korean Diabetes Assoc. 2003; 27:63–72.

8. Papadakis GE, Hans D, Gonzalez Rodriguez E, Vollenweider P, Waeber G, Marques-Vidal P, et al. Menopausal hormone therapy is associated with reduced total and visceral adiposity: the OsteoLaus Cohort. J Clin Endocrinol Metab. 2018; 103:1948–57.

9. Pedersen SB, Kristensen K, Hermann PA, Katzenellenbogen JA, Richelsen B. Estrogen controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha: implications for the female fat distribution. J Clin Endocrinol Metab. 2004; 89:1869–78.

10. Kim EH, Kim HK, Lee MJ, Bae SJ, Choe J, Jung CH, et al. Sex differences of visceral fat area and visceral-to-subcutaneous fat ratio for the risk of incident type 2 diabetes mellitus. Diabetes Metab J. 2022; 46:486–98.

11. Karastergiou K, Smith SR, Greenberg AS, Fried SK. Sex differences in human adipose tissues: the biology of pear shape. Biol Sex Differ. 2012; 3:13.

12. Hanley AJ, Wagenknecht LE, Norris JM, Bryer-Ash M, Chen YI, Anderson AM, et al. Insulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family study. Diabetologia. 2009; 52:2079–86.

13. Karlsson T, Rask-Andersen M, Pan G, Hoglund J, Wadelius C, Ek WE, et al. Contribution of genetics to visceral adiposity and its relation to cardiovascular and metabolic disease. Nat Med. 2019; 25:1390–5.

14. Slentz CA, Aiken LB, Houmard JA, Bales CW, Johnson JL, Tanner CJ, et al. Inactivity, exercise, and visceral fat. STRRIDE: a randomized, controlled study of exercise intensity and amount. J Appl Physiol (1985). 2005; 99:1613–8.

15. Hunter GR, Brock DW, Byrne NM, Chandler-Laney PC, Del Corral P, Gower BA. Exercise training prevents regain of visceral fat for 1 year following weight loss. Obesity (Silver Spring). 2010; 18:690–5.

16. Giannopoulou I, Ploutz-Snyder LL, Carhart R, Weinstock RS, Fernhall B, Goulopoulou S, et al. Exercise is required for visceral fat loss in postmenopausal women with type 2 diabetes. J Clin Endocrinol Metab. 2005; 90:1511–8.

17. Arcidiacono B, Chiefari E, Foryst-Ludwig A, Curro G, Navarra G, Brunetti FS, et al. Obesity-related hypoxia via miR-128 decreases insulin-receptor expression in human and mouse adipose tissue promoting systemic insulin resistance. EBioMedicine. 2020; 59:102912.

18. Strissel KJ, Stancheva Z, Miyoshi H, Perfield JW 2nd, DeFuria J, Jick Z, et al. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes. 2007; 56:2910–8.

19. Moon JS, Goeminne LJ, Kim JT, Tian JW, Kim SH, Nga HT, et al. Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice. Aging Cell. 2020; 19:e13195.

20. Choi MJ, Jung SB, Lee SE, Kang SG, Lee JH, Ryu MJ, et al. An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models. Diabetologia. 2020; 63:837–52.