Korean J Dermatol.  2022 May;60(4):242-253.

A Study on the Correlation of Skin Types with Genetic Factors and Environmental Factors in Koreans

  • 1Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea
  • 2Biomedical Research Institute, Chung-Ang University Hospital, Seoul, Korea
  • 3Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea
  • 4Chungdam Gowoonsesang, Dr.G Dermatology Clinic, Seoul, Korea


The Baumann skin type (BST) classification provides a new approach for clinical care of dermatologic patients.
To investigate the correlation of skin types with genetic factors and environmental factors that have an important influence on Korean skin by comparing and analyzing the correlation between phenotype and genotype.
From July to October 2016, 774 adults who visited the one online shopping mall were subjected to skin BST questionnaire and gene single-nucleotide polymorphism (SNP) tests. Oral epithelial cells of the subjects were collected using a Genoplan DNA analysis kit, and 14 genes were analyzed by a genetic analysis agency (Genoplan Inc., Fukuoka, Japan).
The most abundant skin type was OSNT (oily, sensitive, non-pigmented, tight) observed in 205 participants (26.5%). Of the filaggrin (FLG) SNPs, 143 participants (18.5%) had the GG (good) SNP; 391 (50.5%), GA (normal) SNP; and 240 (31.0%), AA (poor) SNP. Among those whose FLG SNP was GG (good), 121 (84.6%) were sensitive and 22 (15.4%) were resistant. Of those whose filaggrin (FLG) SNP was GA (normal), 337 (86.2%) were sensitive and 54 (13.8%) were resistant. Of those whose FLG SNP was AA (poor), 213 (88.8%) were sensitive and 27 (11.3%) were resistant. There was also a statistically significant difference in the fruit-vegetable consumption and use of a sunbathing bed between sensitive and resistant type in the groups that classified the FLG SNP as GA.
This is the first study to investigate the association of BST with genetic factors and environmental factors.


Dermatology; Environment; Epigenomics; Skin
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