J Korean Assoc Oral Maxillofac Surg.  2022 Apr;48(2):125-129. 10.5125/jkaoms.2022.48.2.125.

Histopathology and ultrastructural findings of pediatric sialolithiasis: a brief communication

Affiliations
  • 1Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea
  • 2Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani, Ghana

Abstract

Sialolithiasis is a condition in which the salivary gland excretory duct is obstructed due to the formation of calcareous deposits and is uncommon in children compared to adults. The treatment modalities range from a conservative approach involving hydration to a surgical approach. Though several studies have analyzed the sialolith micromorphology structures, studies on pediatric sialoliths remain scarce. This brief communication aims to describe the sialolith micromorphology to understand the mechanism of mineralization and growth of pediatric sialoliths. A 6-year-old Korean female presented with swelling under her tongue. The intraoral examination revealed a painless yellowish hard mass beneath the tongue near the Wharton’s duct which was suspected as a sialolith. After receiving the informed consent, the sialolithotomy was performed under local anesthesia. The obtained stone was analyzed through histopathology and transmission electron microscope examinations to understand the mechanism of mineralization and growth of pediatric sialolith. The micromorphology and growth processes of pediatric sialolith remain undescribed. More comprehensive microscopic studies are needed regarding their distinctive characteristics. By expanding knowledge about sialoliths micromorphology, development of new preventive, diagnostic and patient-tailored treatment methods of pediatric sialolithiasis will be enhanced.

Keyword

Pediatrics; Sialolithiasis; Histopathology; Transmission electron microscopy; Ultrastructure

Cited by  1 articles

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Reference

References

1. Thong HK, Mohamad Mahbob H, Sabir Husin Athar PP, Tengku Kamalden TMI. 2020; Recurrent submandibular sialolithiasis in a child. Cureus. 12:e12163. https://doi.org/10.7759/cureus.12163. DOI: 10.7759/cureus.12163. PMID: 33489575. PMCID: PMC7813980.
Article
2. Francis CL, Larsen CG. 2014; Pediatric sialadenitis. Otolaryngol Clin North Am. 47:763–78. https://doi.org/10.1016/j.otc.2014.06.009. DOI: 10.1016/j.otc.2014.06.009. PMID: 25128215.
Article
3. Park SY, Lee SH, Lee NY, Jih MK. 2019; Sialolithiasis in children: three case reports. Oral Biol Res. 43:340–8. https://doi.org/10.21851/obr.43.04.201912.340. DOI: 10.21851/obr.43.04.201912.340.
Article
4. Karengera D, Yousefpour A, Sadeghi HM, Reychler H. 2000; Sialolithiasis in children as a diagnostic dilemma. Eur Arch Otorhinolaryngol. 257:161–3. https://doi.org/10.1007/s004050050215. DOI: 10.1007/s004050050215. PMID: 10839491.
Article
5. Inui A, Itou R, Oyama T, Tamura Y, Kubota K, Kobayashi W. 2017; Comparison of sialolithiasis in pediatric and adult patients. Oral Sci Int. 14:37–9. https://doi.org/10.1016/S1348-8643(17)30019-8. DOI: 10.1016/S1348-8643(17)30019-8.
Article
6. Nolasco P, Anjos AJ, Marques JM, Cabrita F, da Costa EC, Maurício A, et al. 2013; Structure and growth of sialoliths: computed microtomography and electron microscopy investigation of 30 specimens. Microsc Microanal. 19:1190–203. https://doi.org/10.1017/S1431927613001694. DOI: 10.1017/S1431927613001694. PMID: 24001782.
Article
7. Alcure ML, Vargas PA, Jorge Júnior J, di Hipólito Júnior O, Lopes MA. 2005; Clinical and histopathological findings of sialoliths. Braz J Oral Sci. 4:899–903.
8. De-Castro ICV, De Azevedo RA, Campos PSF, dos Santos JN. de-Jesus AAF. 2019; Clinicopathological study of sialolithiasis: a retrospective analysis of 11 cases. J Oral Diagn. 04:e20190006.
9. Busso CS, Guidry JJ, Gonzalez JJ, Zorba V, Son LS, Winsauer PJ, et al. 2020; A comprehensive analysis of sialolith proteins and the clinical implications. Clin Proteomics. 17:12. https://doi.org/10.1186/s12014-020-09275-w. DOI: 10.1186/s12014-020-09275-w. PMID: 32265614. PMCID: PMC7110646.
Article
10. Tretiakow D, Skorek A, Wysocka J, Darowicki K, Ryl J. 2021; Classification of submandibular salivary stones based on ultrastructural studies. Oral Dis. 27:1711–9. https://doi.org/10.1111/odi.13708. DOI: 10.1111/odi.13708. PMID: 33140898.
Article
11. Im YG, Kook MS, Kim BG, Kim JH, Park YJ, Song HJ. 2017; Characterization of a submandibular gland sialolith: micromorphology, crystalline structure, and chemical compositions. Oral Surg Oral Med Oral Pathol Oral Radiol. 124:e13–20. https://doi.org/10.1016/j.oooo.2017.03.011. DOI: 10.1016/j.oooo.2017.03.011. PMID: 28483473.
Article
12. Lee HS, Choi BJ, Choi HJ, Kim SO, Son HK, Song JS, et al. 2009; Sialolithiasis on the mouth floor in a child. J Korean Acad Pediatr Dent. 36:114–8. DOI: 10.12655/kadh.2016.12.1.27.
13. Hayashibara T, Nakano K, Sobue S, Ooshima T. 2004; Salivary calculi in children: a study using an energy dispersive X-ray analyzer and contact microradiography. Pediatr Dent J. 14:41–5. https://doi.org/10.11411/pdj.14.41. DOI: 10.1016/S0917-2394(04)70007-5.
Article
14. Kasaboğlu O, Er N, Tümer C, Akkocaoğlu M. 2004; Micromorphology of sialoliths in submandibular salivary gland: a scanning electron microscope and X-ray diffraction analysis. J Oral Maxillofac Surg. 62:1253–8. https://doi.org/10.1016/j.joms.2003.11.018. DOI: 10.1016/j.joms.2003.11.018. PMID: 15452813.
Article
15. Carvalho PA, Almeida A, Duarte L, Vilar R, Leitão J. Alves de Matos AP. 2007; On the structural diversity of sialoliths. Microsc Microanal. 13:390–6. https://doi.org/10.1017/S1431927607070754. DOI: 10.1017/S1431927607070754. PMID: 17900391.
Article
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