J Clin Neurol.  2022 May;18(3):280-289. 10.3988/jcn.2022.18.3.280.

Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults

• Kim KH
• Kim SH
• Hyun JW
• Kim HJ

• KMID: 2529327
• DOI: http://doi.org/10.3988/jcn.2022.18.3.280

Abstract

Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have recently been established as a biomarker for MOG-antibody-associated disease (MOGAD), which is a distinct demyelinating disease of the central nervous system. Among the diverse clinical phenotypes of MOGAD, myelitis is the second-most-common presentation in adults, followed by optic neuritis. While some features overlap, there are multiple reports of distinctive clinical and radiological features of MOG-IgG-associated myelitis, which are useful for differentiating MOGAD from both multiple sclerosis and neuromyelitis optica spectrum disorder. In this review we summarize the clinical and radiographic characteristics of MOG-IgG-associated myelitis with a particular focus on adult patients.

Keyword

myelin oligodendrocyte glycoprotein; demyelinating diseases; myelitis; multiple sclerosis; neuromyelitis optica spectrum disorder