Tuberc Respir Dis.  1969 Dec;16(4):17-22. 10.4046/trd.1969.16.4.17.

The Influence of Prednisolon on Rabbits Susceptibility to Mycobacterium Tuberculosis Var. Hominis Infection

• KMID: 2529139
• DOI: http://doi.org/10.4046/trd.1969.16.4.17

Abstract

In order to whether prednisolon increases the rabbit's susceptibility to human type mycobacterium, the foIIowing experiment was carried out. Rabbit No. I; 1mg bovine mycobacterium were inoculated subcutaneously. Rabbit No. II, III, lV; 10mg H₃₇Rv were inoculated and 1mg prednisolon was injected daiIy for 6 months. Rabbit No. V, VI; 10mg H₃₇Rv were inoculated. 6 months later. all of the rabbits were sacrificed, and the tissues of the inoculated locations, lungs, spleens, livers, kidneies and omentums were examined macroscopically for gross patology, and viable counts were tested. The results observed are as fallows. Rabbit No. II, III, lV, infected with H₃₇Rv and treated with prednisolon, showed more disseminated and severer taberculosis than the others; NO. I infected with bovine mycobacteria, and No. V and VI, infected with H₃₇Rv without prednisolon treatment. The results observed could be interpreted as a increascd susceptibility of the rabbit to H₃₇Rv by prednisolon treatment.