Tuberc Respir Dis.  1971 Mar;18(1):29-35. 10.4046/trd.1971.18.1.29.

An Experimental Study on Isoniazid alone Intermittent Chemotherapy in Experimental Mouse Tuberculosis

• KMID: 2529113
• DOI: http://doi.org/10.4046/trd.1971.18.1.29

Abstract

This study was designed to observe the effect of 1soniazid alone intermittent chemotherapy in experimental mouse tuberculosis. Author divided the experimental animals into two groups, namely daily and intermittent treatment. Body weight, mortality, macroscopic finding of the lung, viable count and susceptibility test to Isoniazid were carried out on 30th day, 90th day and 180th day. The results were as follow; 1) The change of body weight showed no remarkable difference between daily and intermittent treatment group. 2) The mortality was not different between both groups. 3) Aoki’s macroscopic finding of the lung was not significantly different between both groups. 4) The viable count of the lung was averaged 5.0220 on 30th day, 3.8585 on 90th day and 2.5230 on 180th day in daily treatment, which showed progressively reduction: in the viable count from early stage. In intermittent treatment, the viable count was averaged 5.9704 on 30th day, 5.0390 on 90th day and 2.9375 on 180th day, which showed no remarkable change on 30th and 90th day but markedly reduction in the viable count on 180th day. 5) In susceptibility test to Isoniazid, all of 5 mice were sensitive on 30th day, 3 of 5 were resistant to 2.0-5.0 mcg/ml on 90th day and 4 of 5 were resistant to 1.0-5.0 mcg/ml on 180th day in daily treatment, on the other hand, all sensitive on 30th and 90th day, and 2 of 5 were resistant to 0.2 mcg/ml on 180 th day in intermittent treatment. 6) These results revealed no difference in the therapeutic effects between daily and intermittent treatment, but in the susceptibility test, the resistance was produced later than and the degree of the resistance was lower in intermittent treatment than in daily treatment.