Tuberc Respir Dis.  1982 Sep;29(3):139-147. 10.4046/trd.1982.29.3.139.

The Value of the Serial Serum Carcinoembryonic Antigen (CEA) Measurements in Patients with the Bronchogenic Carcinoma Before and After Non-surgical (radio-and chemotherapy) Therapies

• KMID: 2528824
• DOI: http://doi.org/10.4046/trd.1982.29.3.139

Abstract

To carry out this study twelve cases were selected who were non-surgical candidates. The serial serum CEA concentrations were measured before and after therpies (radiotherapy alone 5, chemotherapy alone 3 and both treatments in 4 patients). For the clinical evaluation, Type I represents progressive rise, to levels greater than 2.5 ng/ml (CEA), tumor progression and patient deterioration. Type II represents progressive decline, initial level greater than 2.5 ng/ml, and tumor response or clinicat improvement. The results were as follow: 1) 10 responses in 8 patients belong to group I or II, but excluded 6 responses in 5 patients from those groups whose initial CEA levels below the 2. 5ng/ml (3) and dubious responses to detemine (2 patients). 2) In radiotherapy group, 6 patients (67 percent) showed correlation between the curves of CEA response and clinical evaluation of disease activity. 4 patients (57 percent) of the chemotherapy group showed correlation between CEA and clinical response. 3) In Type II group, serum CEA concentrations were significantly decreased following each radiotherapy or chemotherapy (p-value < 0.005) but Type I group (p-value>0. 1). 4) These data indicate that serum CEA levels parallel, in general, clinical responses.