J Korean Soc Ther Radiol Oncol.  1999 Mar;17(1):30-35.

Pre-radotherapy and Post-radiotherapy Serial Serum Squamous Cell Carcinoma Antigen (SCC) and Carcinoembryonic Antigen (CEA) in the Monitoring of Squamous Cell Carcinoma of Uterine Cervix

• Yun HG
• Park CH

Abstract

PURPOSE
To evaluate the significance of squaous cell carcinoma antigen (SCC) and carcinoembryonic anti antigen (CEA) as tumor markers in uterine cervix carcinoma.
MATERIALS AND METHODS
In 22 patients with histologically proven primary squamous cell carcinoma of uterine cervix, tumor volume was checked either by using MRI (in 20 patients) or ultrasound (in 2 patients)or ultrasound (in 2 partients). Pre-treatment serum SCC levels were checked in 22 patients and CEA levels in 21 patients. Ather curative radiotherapy, post-treatment SCC and CEA were checked reqularly.
RESULTS
SCC was raised in 68.2% and CEA was raised in 19.0% before treatment. The coefficinoma of correlation between tumor volume and pre-reatment SCC was 0.59382 when one extremely deviated case was excluded . And there was no correlation between tumor volume and CEA. After the treatment , SCC was raised in 9.1% and CEA. After the raise of SCC was associated with clinical relapse or persistence of disease. The specificity of raised SCC level in association with recurrent or persistent disease was 93.8%. The sencificity in association with recurrent or persistent disease was 100%. The positive predictive values was 85.7%. The median lead time for recurrence was 1.2 months.
CONCLUSION
Both SCC and CEA were good tumor for monitoring treatment effect in patints with raised pre-treatment levels. But the sensitivity of pretreatment CEA was low, while that of pretreatment SCC was high. And there was no additional gain by adding CEA measurements to SCC measurements.

Keyword

SCC; CEA; Tumor marker; Uterine cervix cancer; Radiotherapy

MeSH Terms

Carcinoembryonic Antigen*
Carcinoma, Squamous Cell*
Cervix Uteri*
Female
Humans
Magnetic Resonance Imaging
Radiotherapy
Recurrence
Sensitivity and Specificity
Tumor Burden
Biomarkers, Tumor
Ultrasonography
Carcinoembryonic Antigen