Tuberc Respir Dis.  1986 Dec;33(4):216-225. 10.4046/trd.1986.33.4.216.

Ventilatory Dynamics in Pulmonary Tuberculosis

• KMID: 2528683
• DOI: http://doi.org/10.4046/trd.1986.33.4.216

Abstract

Ventilatory dynamics was studied in patients with pulmonary tuberculosis by means of analyses of simultaneously recorded forced expiratory volume (FEV) and maximal expiratory flow volume (MEFV) curves, and determinations of closing volumes. The study population consisted of a total of 263 cases comprizing 124 cases of minimal, 78 moderatly and 61 far advanced pulmonary tuberculosis. On the whole, the mean of various volume and flow parameters derived from FEV and MEFV curves showed progressive decrease as the extent of the disease advanced. In comparisons of the mean of volume-adjusted flow parmeters between patients groups, all were significantly decreased in far advanced cases than that in the remainder, whereas significant differences between minimal and moderately advanced cases were limited to FEV₁ Vmax50 and Vmax25. The mean of the closing volume (CV) and its ratio to VC (CV/VC) tended in far advanced cases was significantly larger than that in the remainder, with no significant difference between minimal and moderately advanced cases. This suggests that far advanced pulmonary tuberculosis is associated with a marked obstruction in large and small airways as well as restrictive ventilatory impairment. It also suggests that a major difference between minimal and moderately advanced cases is that the latter has a significant small airway obstruction compared with the former.