Tuberc Respir Dis.  1986 Dec;33(4):226-233. 10.4046/trd.1986.33.4.226.

Ventilatory Function and Diffusion Capacity of the Lung in Patients with Far Advanced Pulmonary Tuberculosis

• KMID: 2528684
• DOI: http://doi.org/10.4046/trd.1986.33.4.226

Abstract

The authors studied the ventilatory function and diffusion capacity of the lung in patients with far advanced pulmonary tuberculosis from January 1985 to August 1986. The studied subjects were consisted of 80 patients with far advanced pulmonary tuberculosis and comparable with 120 nonsmoking healthy persons as a control. The results obtained were summerized as follows: 1) The parameters derived from forced expiratory volume curve in patients with far advanced pulmonary tuberculosis, FVÇ, FEV₁, FEV₁, %, FEF25-75% and FEF 75-85% , were significantly lower than those of normal control (p < 0.05). 2) The parameters derived from maximal expiratory flow volume curve, PEFR, Vmax 25%, Vmax 75%, were significantly lower than those of normal control(p < 0.05). 3) The parameters derived from forced expiratory volume curve and maximal expiratory flow volume curve in patients with far advanced pulmonary tuberculosis trended to decrease as duration of illness was increased. 4) The parameters of volume-adjusted forced expiratory volume curve and maximal expiratory flow volume curve in patients with far advanced pulmonary tuberculosis trended to decrease as duration of illness was increased. 5) DLco and DLco/ V A in patients with far advanced pulmonary tuberculosis were significantly lower than those of normal control (p < 0.05). 6) In patients with far advanced pulmonary tuberculosis, the lung diffusion capacity was directly related to FVC and FEV₁ (r=0.578, p < 0.001 and r=0.457, p < 0.05). 7) The Pa0₂ and arterial 0₂ saturation in patients with far advanced pulmonary tuberculosis were significantly decreased than those of normal control(p < 0.001 and p < 0.01)but PaC0₂ in patients with far advanced pulmonary tuberculosis was not different as compared with control.