Tuberc Respir Dis.  1989 Mar;36(1):41-46. 10.4046/trd.1989.36.1.41.

Superoxide Production and Myeloperoxidase Activity by Peripheral Neutrophils in the Bronchial Asthmatics

• KMID: 2528573
• DOI: http://doi.org/10.4046/trd.1989.36.1.41

Abstract

Although neutrophils provide a means of defense against bacterial and fungal infection, they can also be destructive to host tissue. In addition, peripheral neutrophils have been implicated in the pathogenesis of various respiratory disorders, including the adult respiratory distress syndrome, emphysema and bronchial asthma. Neutrophils appear to mediate the later phase of inflammatory response in allergic asthma and may accumulate as a result of the release of neutrophil chemoattractants by mast cells. For the evaluation of the role of neutrophils in bronchial asthma, these data analyzed the superoxide production and myeloperoxidase activity of peripheral neutrophils in bronchial asthmatics. Superoxide production by neutrophils after stimulation with 10^-6 M TPA(tetradecanoyl phorbol acetate) was significantly increased after than before oxygen administration in the bronchial asthmatics(p < 0.05). Myeloperoxidase activity of neutrophils after stimulation with 10^-6 M fMLP (N - formyl-methionyl - leucyl - phenylalanine) appear to increase after than before oxygen administration, but statistically not significant in the bronchial asthmatics.