Tuberc Respir Dis.  1990 Mar;37(1):93-99. 10.4046/trd.1990.37.1.93.

A Study on the 2.3-DPG(Diphosphoglycerate) Activity in Red Blood Cells of the Patients with Bronchial Asthma, COPD (Chronic Obstructive Pulmonary Disease) and Pulmonary Tuberculosis

• KMID: 2528516
• DOI: http://doi.org/10.4046/trd.1990.37.1.93

Abstract

Red blood cells synthesize 2.3- DPG that shifts the oxygen dissociation curve to right and consequently, increase the oxygen utilization and metabolism in the peripheral tissue. Recently there are many reports on the 2.3- DPG activity in red blood cell and related factor, ie PH, Temperature hemuglobin, anoxia, bicarbonate, and high altitude. On these fundament al basis. clinically 1 investigate the relationship between 2.3- DPG activity in red blood cell and known environmental factors in bronchial astsma, COPD and pulmonary tuberculosis. The result doesn’t show significant change of 2.3-DPG activity according to each disease. its duration, and its severity. But, it shows a correlation between 2.3- DPG activity and environmental fact ors‘ Especially a arterial oxygen partial pressure shows a reverse correlation with 2.3-DPG activity. These results suggest that 2.3-DPG activity mainly depends on the arterial oxygen partial pressure.