J Korean Ophthalmol Soc.  2022 Apr;63(4):389-395. 10.3341/jkos.2022.63.4.389.

Meibomian Gland Dysfunction Associated with Bortezomib in a Multiple Myeloma Patient

• Yoon DE
• Jun RM
• Han KE

• KMID: 2528331
• DOI: http://doi.org/10.3341/jkos.2022.63.4.389

Abstract

Purpose
This study reports a case of meibomian gland dysfunction associated with bortezomib, which is a treatment of choice for multiple myeloma.
Case summary
A 59‐year‐old female patient presented to our hospital with a complaint of dryness that had worsened for 2 months and eye discharges that were difficult to remove even after washing her face. The patient had been diagnosed with multiple myeloma 5 months prior and had undergone four cycles of bortezomib therapy. Slit‐lamp microscopy revealed a number of pouting of the meibomian gland (MG) orifices in both eyes. Meibography revealed that more than one‐third and less than twothirds of the total MG area of both upper lids were lost and more than two‐thirds of the total MG area of both lower lids were lost. No clinically significant improvements were noted at 8 months despite thorough eyelid hygiene therapy, including warm compresses, topical antibiotics, steroids, and artificial tears. However, when the patient revisited our clinic 2 months after completing bortezomib treatment, the subjective symptoms had improved and all of the pouting of MG orifices had disappeared. There was no significant difference in the MG dropout area for either eye compared with the observations from a previous visit during bortezomib treatment.
Conclusions
Clinicians should be aware that MG dysfunction may occur or worsen in patients receiving bortezomib treatment and should consider this when establishing a treatment plan for meibomian dysfunction or when educating patients.

Keyword

Bortezomib, Dry eye syndrome, Meibomian gland dysfunction, Multiple myeloma