Ann Pediatr Endocrinol Metab.  2022 Mar;27(1):15-21. 10.6065/apem.2142236.118.

Endocrinal dysfunction in children with Down syndrome

Affiliations
  • 1Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt

Abstract

Down syndrome (DS) is the most common genetic disorder in live-born infants. Children with DS are at increased risk of numerous endocrinal comorbidities. The information contained in this article will provide pediatricians with a narrative overview of different presentations, diagnoses, and management recommendations of various endocrinal disorders in children with DS. We systematically searched PubMed, Embase, Google Scholar, MEDLINE, EBSCO, and Science Direct, and potentially relevant articles were identified and retrieved from electronic and print journals.

Keyword

Down syndrome; Hypothyroidism; Obesity; Short stature
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