World J Mens Health.
2022 Apr;40(2):330-339. 10.5534/wjmh.210084.
Genome-Wide Association Analysis to Search for New Loci Associated with Lifelong Premature Ejaculation Risk in Chinese Male Han Population
- Affiliations
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- 1Department of Urology, Hainan General Hospital, Affiliated Hainan Hospital of Hainan Medical University, Haikou, Hainan, China.
- 2Department of Urology, Hainan General Hospital, Affiliated Hainan Hospital to University of South China, Hengyang, Hunan, China.
- 3Department of Urology, Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, China.
- 4Ministry of Science and education, Hainan Women and Children's Medical Center, Haikou, Hainan, China.
- 5Library, Hainan Medical University, Haikou, Hainan, China.
- 6Department of Urology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China, China.
- KMID: 2527331
- DOI: http://doi.org/10.5534/wjmh.210084
Abstract
- Purpose
Genetic factors play an indispensable role in the pathogenesis of lifelong premature ejaculation (LPE). The susceptibility genes/SNPs that have been discovered are very limited and can only explain part of the genetic effects of LPE. Therefore, discovering more genetic polymorphisms associated with the occurrence and development of LPE will help reveal the pathogenesis of LPE.
Materials and Methods
We conducted a genome-wide association study of LPE in 486 Chinese male Han people (cases and controls). We used Gene Titan multi-channel instrument and Axiom Analysis Suite 6.0 software for genotyping. Imputation was performed by IMPUTE2 software and the 1000 Genomes Project (Phase3) was used as reference for haplotype. Finally, logistic regression analysis was performed on all loci that passed the quality control. The odds ratio and 95% confidence interval were calculated to determine the association between each SNPs and Chinese male Han population LPE risk.
Results
The results showed that a total of 33 genetic variants in 13 genes (LACTBL1, SSBP3, ACOT11, LINC02486, TMEM154, LINC01098, NONE, HCG27, HLA-C, TNFSF8, TNC, FAM53B, SULF2) have a suggestively significant genomewide association with LPE risk (p<5×10 -6 ).
Conclusions
This study is the first to conduct a GWAS on LPE in Chinese male Han population 33 genetic polymorphisms have a suggestive genome-wide association with LPE risk. This study have provided data supplement for the genetic loci of LPE risk, and laid a scientific foundation for the pathogenesis and the targeted therapy of LPE.
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